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AG 1295

AG 1295 ??? ???
?? ??:
71897-07-9
???:
AG 1295
???(??):
AG 1295;NSC 380341;AG 1295 USP/EP/BP;TYRPHOSTIN AG 1295;TYROPHOSTIN AG1295;AG-1295 (NSC 380341;AG 1295, 10 mM in DMSO;TYRPHOSTIN AG 1295, 99+%;AG 1295 PLATELET-DERIVED GROW;6,7-DIMETHYL-2-PHENYLQUINOXALINE
CBNumber:
CB5683675
???:
C16H14N2
??? ??:
234.3
MOL ??:
71897-07-9.mol
MSDS ??:
SDS

AG 1295 ??

???
121 °C
?? ?
398.3±37.0 °C(Predicted)
??
1.127±0.06 g/cm3(Predicted)
?? ??
−20°C
???
?????(?? ???), ???????(?? ???)
?? ?? (pKa)
1.29±0.30(Predicted)
??? ??
?? ??
??
???
InChI
1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
InChIKey
FQNCLVJEQCJWSU-UHFFFAOYSA-N
SMILES
n1c2c(ncc1c3ccccc3)cc(c(c2)C)C

??

????? 22-24/25
WGK ?? 3
???? ??? 11 - Combustible Solids

AG 1295 C??? ??, ??, ??

??

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 μM). It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 μM without affecting activity of the EGF receptor.

??

AG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.

AG 1295 ?? ?? ? ???

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AG 1295 ?? ??

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