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PI3K???

PI3K??? ??? ???

?? ??:: 1202884-94-3

???:: PI3K???

???(??):: PI3K???

???:: PI3K inhibitor

???(??):: CAY10626;PI3K-IN-22;Antitumor Drug;PI3K inhibitor;CAY10626, PI3Kalpha/mTOR inhibitor;N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide;BenzaMide, N-[2-(diMethylaMino)ethyl]-N-Methyl-4-[[[[4-[4-(4-Morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyriMidin-2-yl]phenyl]aMino]carbonyl]aMino]-

CBNumber:: CB62487667

???:: C31H35F3N8O3

??? ??:: 624.66

MOL ??:: 1202884-94-3.mol

?? ?? 36

PI3K??? ??

??: 1.35±0.1 g/cm3(Predicted)

?? ??: Store at -20°C

???: DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml

??? ??: ??? ??

?? ?? (pKa): 13.74±0.70(Predicted)

??: White to light yellow

??

PI3K??? C??? ??, ??, ??

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The PI3Kinases are important downstream effectors of KRAS signaling. In preclinical studies, buparlisib (BKM120), a PI3K inhibitor, when combined with MEK inhibitor (PD1056309) led to significant synergistic activity in KRAS mutant NSCLC cell lines.

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