ChemicalBook >?? ???? >2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester
2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester
|
|
2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester ??
- ?? ??
- Keep in dark place,Inert atmosphere,Room temperature
- ??
- White to light brown Solid
- InChI
- InChI=1S/C12H16BN3O2/c1-11(2)12(3,4)18-13(17-11)9-5-8(6-14)10(15)16-7-9/h5,7H,1-4H3,(H2,15,16)
- InChIKey
- KRNXYPYYVHFVQS-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1C#N
??
| HS ?? | 2933399990 |
|---|
2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester C??? ??, ??, ??
Synthesis
2-amino-5-bromonicotinonitrile (50 g, 0.224 mol), bis (pinacolato) diboron (85.6 g, 0.337 mol), KOAc (44.1 g, 0.449 mol) and Pd (dppf) Cl2. CH2C12 (2.77 g, 3.4 mmol) was charged into a flask. Dioxane (400 mL) was added. The reaction mixture was stirred at 100 ℃ for 2 h under Ar. When LC-MS indicated that the reaction was completed, the mixture was cooled to room temperature. Subsequently, the mixture was filtered through diatomite, concentrated, diluted with a mixture of ethyl acetate and hexane (3:1, 1000 mL), filtered through silica gel (300-400 mesh), concentrated, crystallized and dried to give 2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester (32 g, 66%) as a white solid.
2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester ?? ?? ? ???
???
?? ??
2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester ?? ??
???( 38)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 52923 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 |
sales1@artkmedchem.com | China | 39021 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131956 | 58 |
| Tetranov Biopharm | 13526569071 |
sales@leadmedpharm.com | China | 7888 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 |
marketing@accelachem.com | China | 10975 | 64 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 |
sales@shiyabiopharm.com | China | 4169 | 58 |
2-Amino-3-cyanopyridine-5-boronic Acid Pinacol Ester ?? ??:
N,3-diMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine
3-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile
3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
3-Pyridinecarbonitrile, 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
2-(methylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile