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N-(3-??????)-?????????

N-(3-??????)-????????? ??? ???

?? ??:: 183718-75-4

???:: N-(3-??????)-?????????

???(??):: N-(3-??????)-?????????

???:: N-(3-hydroxyphenyl)-Arachidonoyl amide

???(??):: N-(3-hydroxyphenyl)-Arachidonoyl amide;N-(3-hydroxyphenyl)-Arachidonoyl amide Exclusive;(5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide;5,8,11,14-Eicosatetraenamide, N-(3-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-

CBNumber:: CB62591788

???:: C26H37NO2

??? ??:: 395.58

MOL ??:: 183718-75-4.mol

?? ?? 16

N-(3-??????)-????????? ??

?? ?: 579.4±50.0 °C(Predicted)

??: 1.007±0.06 g/cm3(Predicted)

?? ??: Store at -20°C

???: ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide

??? ??: solution in ethanol.

?? ?? (pKa): 9.57±0.10(Predicted)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H225	???? ?? ? ??	??? ??	?? 2	??		P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??		P264, P280, P305+P351+P338,P337+P313P

??????:

P210	?·???·??·????? ????? - ?? ???.
P233	??? ??? ?????. ??? ??? ? ?? ?? ??? ???? ?????.
P240	??? ????? ?? ? ??????.
P241	?? ??? ??[???/??/??/...]?(?) ?????.
P242	???? ???? ?? ??? ?????
P243	??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P280	????/???/???/?????? ?????.
P303+P361+P353	??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.
P370+P378	?? ? ?? ?? ?? (Section 5. ??, ??? ????? ??? ???)?(?) ?????.
P403+P235	??? ? ?? ?? ???? ???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	3
2		0

N-(3-??????)-????????? C??? ??, ??, ??

??

N-(3-hydroxyphenyl)-Arachidonoyl amide (3-HPA) is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), which is a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide (AEA). 3-HPA is metabolized by both cyclooxygenase-1 (COX-1) and COX-2 and was found to selectively and irreversibly inhibit COX-2 with an IC₅₀ value of 2 μM.

N-(3-??????)-????????? ?? ?? ? ???

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N-(3-??????)-????????? ?? ??

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