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N-BOC-IMIDAZOLE

N-BOC-IMIDAZOLE ??? ???
?? ??:
49761-82-2
???:
N-BOC-IMIDAZOLE
???(??):
tert-Butyl 1H-imidazole-1-carboxylate;N-TERT-BUTOXYCARBONYLIMIDAZOLE;tert-Butyl imidazole-1-carboxylate;BOC-IMIDAZOLE;N-BOC-IMIDAZOLE;1-Boc-imidazole;N-T-BOC-IMIDAZOLE;N-Boc-imidazole,98%;1-Boc-imidazole, 98%;Medetomidine Impurity 58
CBNumber:
CB6328955
???:
C8H12N2O2
??? ??:
168.19
MOL ??:
49761-82-2.mol

N-BOC-IMIDAZOLE ??

???
45-47 °C(lit.)
?? ?
147-150 °C(lit.)
??
1.1835 (rough estimate)
???
1.4200 (estimate)
???
>230 °F
?? ??
2-8°C
???
??, ??? ? DMF? ?????.
?? ?? (pKa)
3.49±0.10(Predicted)
??? ??
powder to crystal
??
???? ?? ??
??
Moisture Sensitive
BRN
607792
InChI
InChI=1S/C8H12N2O2/c1-8(2,3)12-7(11)10-5-4-9-6-10/h4-6H,1-3H3
InChIKey
MTBKGWHHOBJMHJ-UHFFFAOYSA-N
SMILES
C1N(C(OC(C)(C)C)=O)C=CN=1
CAS ??????
49761-82-2(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-36
WGK ?? 3
HS ?? 2933299090
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
2 0

N-BOC-IMIDAZOLE C??? ??, ??, ??

??? ??

White powder

??

1-Boc-imidazole is used in the preparation of water soluble polyrotaxane, via modification of α-cyclodextrin in the presence of KOH and N,N-carbonyldiimidazole.

Synthesis Reference(s)

1. (a) Barcelo, G.; Senet, J. P.; Sennyey, G. JOC 1985, 50, 3951. (b) Klee, W.; Brenner, M. HCA 1961, 2151.

?? ??

1-(tert-butoxycarbonyl)imidazole is an imidazole derivative. Its gas-phase elimination kinetics study has been studied both theoretically and experimentally.

Synthesis

1-(t-butoxycarbonyl)imidazole can be synthesized by the reaction of imidazole and 1,2,2,2-tetrachloroethyl-t-butyl carbonate or the reaction of t-butanol and N,N′-carbonyldiimidazole in high yield.1

N-BOC-IMIDAZOLE ?? ?? ? ???

???

?? ??


N-BOC-IMIDAZOLE ?? ??

???( 174)?? ??
??? ?? ??? ?? ?? ? ??
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N-BOC-IMIDAZOLE ?? ??:

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