5-Fluorouridine
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5-Fluorouridine ??
- ???
- 182-184 °C
- ??
- 17 º (c=2, water 25 ºC)
- ??
- 1.4200 (estimate)
- ???
- 18 ° (C=1, H2O)
- ?? ??
- 2-8°C
- ???
- DMSO(?? 50mg/ml), ?(?? 50mg/ml) ?? ???(?? ? ?? 6mg/ml)? ?????.
- ??? ??
- ??
- ?? ?? (pKa)
- 7.63±0.10(Predicted)
- ??
- ???
- ???? ??
- synthetic (organic)
- ???
- ??
- BRN
- 33662
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO, ??? ?? ???? ??? ??? -20°C?? ?? 3?? ?? ??? ? ????.
- InChI
- 1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
- InChIKey
- FHIDNBAQOFJWCA-UAKXSSHOSA-N
- SMILES
- OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O
- CAS ??????
- 316-46-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 40-68-36/37/38 | ||
| ????? | 22-26-36/37-36/37/39-27-24/25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | YU8050000 | ||
| F ?????? | 10 | ||
| ?? ?? ?? | Harmful | ||
| HS ?? | 29349990 | ||
| ???? ??? | 11 - Combustible Solids |
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||
| ??·?? ??: |
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5-Fluorouridine C??? ??, ??, ??
??? ??
White Powder??
5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.??
ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.?? ??
5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.Purification Methods
5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]5-Fluorouridine ?? ?? ? ???
???
?? ??
5-Fluorouridine ?? ??
???( 261)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29626 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
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| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3004 | 60 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 903 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 |
sales@unisyn.cn | CHINA | 332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | |
sales@conier.com | China | 49906 | 58 |
| career henan chemical co | +86-0371-86658258 |
factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 |
5-Fluorouridine ?? ??:
5-??????? ??? 5-????-2'-??????
5-Fluorouridine
2'-DEOXY-2'-FLUOROURIDINE,2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE)
DMT-2′Fluoro-dU Phosphoramidite
5-Fluoropyrimidine
Doxifluridine
5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine
2'-DEOXY-5-FLUOROURIDINE, [3H]-
3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE
2',3'-DIDEOXY-3'-FLUOROURIDINE
5'-Deoxy-2',3'-O-isopropylidene-5-fluorouridine
2',3'-dideoxy-5-fluorouridine
5-Fluorouridine
2'-Deoxy-5-fluorouridine 3',5'-dioctanoate
2'-Deoxy-5-fluorouridine 3',5'-dibutanoate
5'-O-(9-Octadecenoyl)-5-fluorouridine