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N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine

N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine ??? ???
?? ??:
1438071-12-5
???:
N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine
???(??):
GSK-2945;GSK-2945 (GSK2945 );GSK 2945 DISCONTINUED. Please see G797405;2-Thiophenemethanamine, N-[(4-chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-;N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine
CBNumber:
CB63464337
???:
C20H18Cl2N2O2S
??? ??:
421.34
MOL ??:
1438071-12-5.mol

N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine ??

?? ?
525.0±45.0 °C(Predicted)
??
1.363±0.06 g/cm3(Predicted)
???
Acetonitrile (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
?? ?? (pKa)
5.23±0.50(Predicted)
??? ??
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N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine C??? ??, ??, ??

??

GSK 2945 is an antagonist with high specificity for REV-ERBα, Nuclear heme receptor reverse erythroblastosis virus, which is known to regulate circadian rhythm and more specifically, regulation of cholesterol 7α-hydroxylase (CYP7A1) and bile acid synthesis.

N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine ?? ?? ? ???

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N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine ?? ??

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