Mizoribine
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Mizoribine ??
- ???
- >2000C
- ??
- D27 -35° (c = 0.8 in H2O)
- ?? ?
- 402.47°C (rough estimate)
- ??
- 1.4155 (rough estimate)
- ???
- 1.5100 (estimate)
- ?? ??
- 2-8°C
- ???
- DMSO(?? ???), ?(?? ???)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 6.75(at 25℃)
- ??
- ???? ?????
- ?? ??(λmax)
- 280nm(lit.)
- Merck
- 14,6222
- InChI
- InChI=1/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/s3
- InChIKey
- HZQDCMWJEBCWBR-UUOKFMHZSA-N
- SMILES
- C1N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(O)=C(C(N)=O)N=1 |&1:2,4,7,9,r|
- CAS ??????
- 50924-49-7(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 46-60-61-36/37/38 | ||
| ????? | 53-22-26-36/37/39-45 | ||
| WGK ?? | 3 | ||
| RTECS ?? | NI3980000 | ||
| HS ?? | 29349990 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Eye Irrit. 2 Repr. 1B Skin Irrit. 2 STOT SE 3 |
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| ?? | LD50 in mice (g/kg): >1.5 i.v., >2.4 i.p. (Mizuno, 1975) |
Mizoribine C??? ??, ??, ??
??
Mizoribine is an orally active immunosuppressant isolated from Eupenicillium brefeldianum. It is reported to inhibit both cell-mediated and antibody mediated immune responses. Mizoribine is approved for use in the prevention of rejection of kidney transplants.??? ??
Crystalline Solid??
Mizoribine has been used in topical treatment to evaluate its effect on ocular surface damage of dry eye in B6 mice subjected to desiccating stress (DS). It has also been used as an inosine monophosphate dehydrogenase (IMPDH) inhibitor to test its in vivo efficacy.Mizoribine ?? ?? ? ???
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?? ??
Mizoribine ?? ??
???( 310)?? ??
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|---|---|---|---|---|---|
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