ChemicalBook >?? ???? >??? ??>???>?? ? ?? ??? ???? (MAPK)>Raf ???>ZM 336372

ZM 336372

ZM 336372 ??? ???

?? ??:: 208260-29-1

???:: ZM 336372

???(??):: CS-44;ZM 336372;Zinc00581684;ZM 336372, >=98%;ZM 336372 ，S2720;Probucol (DH-581);ZM 336372;ZM-336372;ZM 336372 USP/EP/BP;ZM 336372, 10 mM in DMSO;ZM 336372; ZM-336372;ZINC00581684

CBNumber:: CB6428631

???:: C23H23N3O3

??? ??:: 389.45

MOL ??:: 208260-29-1.mol

MSDS ??:: SDS

?? ?? 170

ZM 336372 ??

?? ?: 484.4±45.0 °C(Predicted)

??: 1.298

?? ??: Keep in dark place,Sealed in dry,2-8°C

???: ? ??? DMSO: >5mg/mL(??)

?? ?? (pKa): 8.31±0.15(Predicted)

??? ??: ??

??: ???? ????

??: Light Sensitive

???: ??? ?? ?????? 2? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.

InChI: 1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

InChIKey: PYEFPDQFAZNXLI-UHFFFAOYSA-N

SMILES: N(C)(C)c1cc(ccc1)C(=O)Nc2cc(c(cc2)C)NC(=O)c3ccc(cc3)O

?? ? ?? ??
?? ? ???? ?? (GHS)

WGK ??	3
HS ??	2924297099
???? ???	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 4 Skin Sens. 1B

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H317	????? ?? ??? ??? ? ??	?? ??? ??	?? 1	??		P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H413	??? ??? ?? ????? ??? ??? ??	?? ????? ?? - ??	?? 4

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P272	??? ??? ??? ??? ???? ???.
P273	???? ???? ???.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P333+P313	????? ?? ??? ???? ???? ??·??? ????.

NFPA 704

	0
2		0

ZM 336372 C??? ??, ??, ??

??

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

ZM 336372 ?? ?? ? ???

???

?? ??

ZM 336372 ?? ??

???( 170)?? ??

???	??	???	??	?? ?	??
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	963	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9976	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11674	58
Aladdin Scientific		tp@aladdinsci.com	United States	57473	58

ZM 336372 ?? ??:

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE ZM223 Z-N-Methyl-D-valine ZOTAROLIMUS ZPCK ZM 323881 hydrochloride ZM 39923 HCl ZM 241385 ZM 306416 SB216763 ZM 447439 Z-NVA-OH ZM 39923 HYDROCHLORIDE Z-NLE-OH ZM306416 Z-L-Orn(Boc)-OH Quizartinib

一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线