Cyproheptadine hydrochloride sesquihydrate
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Cyproheptadine hydrochloride sesquihydrate ??
- ???
- 165 °C (dec.)(lit.)
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- ???: ???
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?? ???
- ?? ??(λmax)
- 285nm(0.05mol/L H2SO4)(lit.)
- Merck
- 14,2773
- InChI
- InChI=1S/C21H21N.ClH.H2O/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;/h2-11H,12-15H2,1H3;1H;1H2
- InChIKey
- PFQPCBUPUOPHGM-UHFFFAOYSA-N
- SMILES
- CN1CCC(=C2C3C=CC=CC=3C=CC3=CC=CC=C23)CC1.Cl.O
- CAS ??????
- 41354-29-4(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38 | ||
| ????? | 26-36 | ||
| ????(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | TM7050000 | ||
| ?? ?? | 6.1 | ||
| ???? | III | ||
| HS ?? | 29333990 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| ?? | LD50 orally in mice: 74.2 mg/kg (Loux) |
Cyproheptadine hydrochloride sesquihydrate C??? ??, ??, ??
??? ??
White or slightly yellow, crystalline powder.??
Cyproheptadine hydrochloride sesquihydrate has been used in:- testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
- the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
- the inhibition of 5-HT in embryo physiological experiments
inhibition of calcitonin gene related peptide (CGRP)
??
ChEBI: The sesquihydrate of cyproheptadine hydrochloride. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate. A sedating antihistamine with antimuscarinic and calcium-channel blocking actions, it i used for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.?? ??
Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine. It induced preventive effect against the development of pergolide-induced valvulopathy in a rat model.Cyproheptadine hydrochloride sesquihydrate ?? ?? ? ???
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Cyproheptadine hydrochloride sesquihydrate ?? ??
???( 383)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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Cyproheptadine hydrochloride sesquihydrate ?? ??:
?????? ?????????? ????????? ???????????? ??(2-)-2-??-6-? 2,2,6,6-???-4-????? 1,3,5-??????? ?????
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