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???? ??? ???
?? ??:
67227-56-9
???:
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???(??):
????
???:
Fenoldopam
???(??):
SKF-82526;CS-1332;Corlopam;FENOLDOPAM;SKF-82526-J;CORLOPAM MESYLATE;Fenoldopam, Corlopam;Fenoldopam USP/EP/BP;Fenoldopam hydrochlo;FenoldopamMesylateBase
CBNumber:
CB6729842
???:
C16H16ClNO3
??? ??:
305.76
MOL ??:
67227-56-9.mol

???? ??

?? ?
522.6±50.0 °C(Predicted)
??
1.380±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO: >12 mg/mL
?? ?? (pKa)
8.50±0.40(Predicted)
??? ??
??
??
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InChI
InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
InChIKey
TVURRHSHRRELCG-UHFFFAOYSA-N
SMILES
N1CCC2=C(Cl)C(O)=C(O)C=C2C(C2=CC=C(O)C=C2)C1
CAS ??????
67227-56-9(CAS DataBase Reference)

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??? ?? Xn
?? ???? ?? 22-36-42/43
????? 22-26-36/37/39
WGK ?? 3

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The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Fenoldopam is a selective dopamine 1 receptor agonist with diuretic and properties (2,3).

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Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM).

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