ChemicalBook >?? ???? >5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde ??? ???

?? ??:: 231278-84-5

???:: 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

???(??):: lapatinib intermediate;5-[4-[[3-ChL;)methoxy]phenyL;]-2-furancarboxaL;]amino]-6-quinazoL;Lapatinib Impurity 5;Lapatinib impurity J;Lapatinib Impurity 08;Lapatinib Intermediate 3;Lapatinib Formyl Impurity

CBNumber:: CB71175948

???:: C26H17ClFN3O3

??? ??:: 473.88

MOL ??:: 231278-84-5.mol

?? ?? 305

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde ??

???: 227.0 to 231.0 °C

?? ?: 650.3±55.0 °C(Predicted)

??: 1.407±0.06 g/cm3(Predicted)

?? ??: under inert gas (nitrogen or Argon) at 2–8 °C

???: DMSO(?? ???), ???(?? ??)

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 5.18±0.30(Predicted)

??: ????? ?? ????

CAS ??????: 231278-84-5(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde C??? ??, ??, ??

??? ??

Dark Brown Solid

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde ?? ?? ? ???

???

5-?????-2-???,??????? N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine 2-Formylfuran-5-boronic acid N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-aMine drochloride 6-Bromo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine 5-?????-2-???,???????????

?? ??

Lapatinib ditosylate monohydrate ????

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde ?? ??

???( 305)?? ??

???	??	???	??	?? ?	??
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5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde ?? ??:

??? P-???? 6-??? ???? ??????????? ?????? ?????? ? ??????? ??? ??????? ???? ???? ?????????? 5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione 3-Chloro-4-(3-fluorobenzyloxy)aniline PHENYL VALERATE 4-Methoxyphenylacetone 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone 4-Methoxybenzoic acid

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