ChemicalBook >?? ???? >N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2

N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2

N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2 ??? ???

?? ??:: 251647-50-4

???:: N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2

???(??):: N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2

???:: 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine

???(??):: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide;5'-O-DMT-2'-O-MOE-N2-ibu-rG;DMT-MOE-rG(iBu);N2-iBu-DMT-2'-O-MOE-Gr;N2-iBu-2'-MOE-5'-O-DMT-G;5'-O-DMT-N2-Ibu-2'-OMe-G;5'-O-DMT-2'-O-MOE-G(ibu);5'-O-DMTr-2'-O-MOE-rG(iBu);5'-ODMT-2'-OMOE-N-iBu Guanosine;5'-O-DMT-2’-MOE-N2-iBu-Guanosine

CBNumber:: CB71482846

???:: C38H43N5O9

??? ??:: 713.78

MOL ??:: 251647-50-4.mol

?? ?? 82

N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2 ??

???: 112.5-126.6 °C(Solv: hexane (110-54-3))

??: 1.33±0.1 g/cm3(Predicted)

?? ?? (pKa): 9.16±0.20(Predicted)

InChIKey: XDLPRZLZAFJSMA-JKILKRELNA-N

SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OCCOC)[C@@H]1O |&1:25,27,44,50,r|

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?? ? ???? ?? (GHS)

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Warning

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??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

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P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P271	?? ?? ??? ? ?? ???? ?????.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P330	?? ?????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2 C??? ??, ??, ??

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5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine is an oligonucleotide analogue which is being researched for the treatment of a wide variety of diseases, cancers, and conditions.

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5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine is an antiviral monophosphate nucleoside. It is a modified nucleic acid analogue that acts as an activator of ribonucleotide reductase and DNA polymerase. The anticancer activity of this product may be due to its ability to inhibit the synthesis of diphosphate nucleotides.

N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2 ?? ?? ? ???

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N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2 ?? ??

???( 82)?? ??

???	??	???	??	?? ?	??
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N2-ISOBUTYRYL-5,O-(4,4-???????)-2-O-(2 ?? ??:

5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine 5'-O-DMTr-N2-isobutyrylguanosine 5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine N2-Isobutyryl-5'-O-(4,4-Dimethoxytrityl)-2'-deoxyguanosine-3'-succinate, TEA salt DMT-2μ-O-Me-rG(ib) amidite N2-iso-Butyroyl-5'-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine

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