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- 641.3±55.0 °C(Predicted)
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- 1.34
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- Store at -20°C
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- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
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- ?? ?? (pKa)
- 15.18±0.60(Predicted)
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- White to off-white
- JECFA Number
- 75
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Derquantel is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes. A combination of derquantel and the macrocyclic lactone, abamectin , has been found to have synergistic anthelmintic effects against gastrointestinal nematode parasites in sheep.??
Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel isa potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.??? ?? ?? ? ???
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