Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg(Wohl, 1974).
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KE-27444
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Warning
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P- ??
H410
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P273, P391, P501
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P273
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P391
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P501
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AMBRETTOLIDE C??? ??, ??, ??
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AMBRETTOLIDE is not reported as being found in nature, in contrast
to (Z)-7-hexadecen-16-olide, which occurs in ambrette seed oil
and which is also referred to as ambrettolide. It is a colorless to slightly yellow
liquid, d204 0.949–0.957, n20D 1.477–1.482, with an intense and powerful musk
odor. It is prepared by treating aleuritic acid (9,10,16-trihydroxyhexadecanoic
acid) with trimethyl orthoformate to give a dioxolane derivative. Reaction with
acetic anhydride yields -acetoxy (E)-9-hexadecenoic acid methyl ester. This is
lactonized with potassium hydroxide to give the title compound .
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Found in oil of ambrette seed[Givaudan Index, 1961).
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From bromohexadecenoic acid(Bedoukian, 1967).
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Many patented methods are known, few are commercially feasible. From Bromo hexadecenoic acid, or from Dihydroxy palmitic acid, or from Aleuritic acid, or from Juniperic acid, etc.
