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??????? ?????
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?? ??:
5874-97-5
???:
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???(??):
????????????;????????????(METAPROTERENOLHEMISULFATE);???????????
???:
Orciprenaline sulfate
???(??):
METAPROTERENOL SULFATE;alupent;alotec;th-152;metaprel;Astmopent;novasmasol;ORCIPRENALINE SULFATE;dl-Orciprenaline sulfate;METAPROTERENOLSULFATE,USP
CBNumber:
CB7226328
???:
C22H36N2O10S
??? ??:
520.59
MOL ??:
5874-97-5.mol

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???
202-203°
?? ??
2-8°C
???
?? ? ??, ???(96%)? ?? ???, ??????? ?? ?? ????.
??? ??
Solid
??
???? ?????
???
???
?? ??
???(???)
InChI
1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8;1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4)
InChIKey
MKFFGUZYVNDHIH-UHFFFAOYSA-N
SMILES
OS(O)(=O)=O.CC(C)NCC(O)c1cc(O)cc(O)c1.CC(C)NCC(O)c2cc(O)cc(O)c2
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 20
????? 36
WGK ?? 2
RTECS ?? DO2275000
HS ?? 2922504500
???? ??? 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Inhalation
?? LD50 in rats (mg/kg): 42 orally (Goldenthal)
???? ?? KE-20645
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? P261, P271, P304+P340, P312
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
NFPA 704
0
3 0

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White or almost white, slightly hygroscopic, crystalline powder.

??

Beta2-adrenoceptor agonist; bronchodilator.

Pharmacokinetics

Metaproterenol is a direct-acting resorcinol analogue of isoproterenol. The N-isopropyl is β-directing, and the combination with the resorcinol ring system enhances the selectivity for the β2-receptors. It is the least potent of the β2-selective agonists, however, most likely because of the poor β2-selectivity of the isopropyl group. It has good oral bioavailability being resistant to COMT and only slowly metabolized by MAO. When administered orally, it has an onset of approximately 30 minutes with a 4-hour duration. Inhaled metaproterenol can have an onset as quick as 5 minutes; however, it can be as long as 30 minutes in susceptible individuals. Metaproterenol is available in tablet, syrup, and inhalation dosage forms and is recommended for bronchial asthma attacks and treatment of acute asthmatic attacks in children 6 years of age and older (5% solution for inhalation only). Metaproterenol has the same adverse effect profile as other adrenergic agonists, but with a decreased incidence of arrhythmias.

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