ChemicalBook >?? ???? >??? ??>???>????>Chk ???>3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide ??? ???

?? ??:: 860352-01-8

???:: 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide

???(??):: White solid;CS-314;AZD 7762;AZD7762; AZD-7762;AZD-7762 Chk Inhibitor;AZD-7762, 10 mM in DMSO;1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea;(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide;5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide;3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide

CBNumber:: CB72473926

???:: C17H19FN4O2S

??? ??:: 362.42

MOL ??:: 860352-01-8.mol

?? ?? 155

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide ??

?? ?: 547.6±50.0 °C(Predicted)

??: 1.38

?? ??: -20°

???: DMSO? ?????(?? 25mg/ml).

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 9.06±0.20(Predicted)

??: ??? ?? ??

???: ??? ?? 1? ?? ??????. DMSO? ???? ?? 1?? ?? -20°?? ??? ? ????.

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??		P264, P270, P301+P312, P330, P501
H318	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 1	??		P280, P305+P351+P338, P310

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P310	?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
P330	?? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
3		0

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide C??? ??, ??, ??

??

Actively proliferating cells experience blocks at certain checkpoints in the cell cycle when DNA damage is detected. These checkpoints allow for DNA damage repair before further cell cycle progression. Targeting signaling pathways to selectively inhibit repair at these checkpoints in tumor cells is of considerable interest to cancer therapeutics. AZD 7762 selectively inhibits the activity of checkpoint kinases (Chk) 1 and Chk2 (IC₅₀s = 5 nM) by competitively and reversibly binding their respective ATP-binding sites (K_i = 3.6 nM for Chk1). AZD 7762 abrogates DNA damage-induced S and G₂ checkpoints with an EC₅₀ value of 10 nM and potentiates the efficacy of DNA-damage repair prohibitive agents, gemcitabine and topotecan, both in vitro and in various tumor xenografts by modulating downstream checkpoint pathway proteins.

??

AZD 7762 is studied as an cancer therapeutic agent due to its selective inhibitory activities towards checkpoint kinases, chk1 and chk2 by reversibly binding their respective ATP-binding sites within tumor cells. Recent research has also indicated AZD 7762 to possess enhancing effects towards other chk1 inhibitor lethality in glioblastoma cells.

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide ?? ?? ? ???

???

?? ??

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide ?? ??

???( 155)?? ??

???	??	???	??	?? ?	??
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3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide ?? ??:

?????|HMPL-013 PLX4032 Pomalidomide METHOPRENE ACID Levetiracetam 5-(2,6-dichloro-phenylMethanesulfonyl)-1,3-dihydro-indol-2-one MK-1775 MK-8776 (SCH 900776) CHIR-124 ABT 263 Olaparib

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