Vortioxetine hydrobromide
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Vortioxetine hydrobromide ??
- ???
- >223°C (dec.)
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- Refrigerator
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- DMSO(?? ???), ???(?? ???)
- ??? ??
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- InChI
- InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
- InChIKey
- VNGRUFUIHGGOOM-UHFFFAOYSA-N
- SMILES
- S(C1C=CC(C)=CC=1C)C1C=CC=CC=1N1CCNCC1.Br
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- ?? ? ???? ?? (GHS)
| WGK ?? | WGK 3 | ||
|---|---|---|---|
| HS ?? | 29339900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Repr. 2 STOT RE 2 |
Vortioxetine hydrobromide C??? ??, ??, ??
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Vortioxetine Hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).??
ChEBI: Vortioxetine hydrobromide is a hydrobromide obtained by combining vortioxetine with one molar equivalent of hydrobromic acid. Used for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic antagonist and a serotonergic agonist. It contains a vortioxetine(1+).Synthesis
As the picture 2 showed, we have developed a new and practical synthetic route to vortioxetine hydrobromide on a hectogram scale. Adopting commercially available materials, through simple and traditional steps, including nucleophilic substitution, catalytic hydrogenation, and cyclization of the piperazine ring, gave the final product in 63.2% yield over three steps and with 99.3% purity (HPLC). Purification methods for the intermediates involved in the route are also given.
Pic.3 A new synthetic route to vortioxetine hydrobromide
Solubility in water
Vortioxetine hydrobromide is slightly soluble in water; at ambient temperature solubility is equivalent to approximately 1.3 mg base/mL, pH being 5.5 in the saturated solution.Mode of action
Vortioxetine Hydrobromide is a hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine.Vortioxetine hydrobromide ?? ?? ? ???
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2,4-Dimethylbenzenethiol
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2-????-1-YL-????
2-((2,4-?????)??)????
1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene
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4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester
1-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine Hydrochloride
4-IODO-M-XYLENE
2-BROMOTHIOPHENOL
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Vortioxetine hydrobromide ?? ??
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Vortioxetine hydrobromide ?? ??:
tadalafi
di(2,4-xylyl) disulphide
Vorapaxar Sulfate
Vortioxetine
Vortioxetine iMpurity
Choline Fenofibrate
Pazopanib
Selumetinib
Axitinib
Bexarotene
Dasatinib
Benztropine mesylate
1-[2-[(2,6-diMethylphenyl)thio]phenyl]- Piperazine
Vortioxetine Impurity 34
Vortioxetine Impurity 25
Wortoxime hydrobromide impurity A
Wortoxime Hydrobromide Impurity C
Wortoxime hydrobromide impurity F