????????
|
|
???????? ??
- ???
- >235°C (dec.)
- ?? ?
- 725.6±70.0 °C(Predicted)
- ??
- 1.75±0.1 g/cm3(Predicted)
- ?? ??
- under inert gas (nitrogen or Argon) at 2-8°C
- ???
- DMSO(?? ??? ??)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 1.81±0.10(Predicted)
- ??
- ???? ?????
- ???
- ???
- InChIKey
- QCGUSIANLFXSGE-GFCCVEGCSA-N
- SMILES
- O1[C@@H](COP(O)(O)=O)CN(C2=CC=C(C3=CC=C(C4=NN(C)N=N4)N=C3)C(F)=C2)C1=O
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
???????? C??? ??, ??, ??
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Tedizolid phosphate was approved by the US FDA in June 2014 for treatment of acute bacterial skin and skin structure infections caused by susceptible gram-positive pathogens, including MRSA. Tedizolid phosphate was discovered by Dong-A Pharmaceuticals in South Korea and developed in the USA by Cubist Pharmaceuticals (acquired from Trius Therapeutics in 2013, became a wholly owned subsidiary of Merck in 2015). The worldwide commercialization rights for tedizolid phosphate are divided between Cubist in the USA, Canada, and EU, and Bayer in Asia–Pacific, Latin America, and Africa. This second-generation oxazolidinone prodrug is rapidly converted to the active form tedizolid in the presence of endogenous phosphatases. It inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit of the ribosome, preventing formation of the 70S ribosomal initiation complex, and is 4-fold to 16-fold more potent against staphylococci and enterococci compared to linezolid. 251 With high oral bioavailability (approximately 90%) and long half-life (approximately 12 hours), tedizolid phosphate is the first oxazolidinone antibiotic which can be dosed once daily either orally or intravenously.??
Tedizolid, known as TR-700, is an oral and i.v administered intracellular antibacterial drug.??
ChEBI: A phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid . It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptibl bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.???
Tedizolid phosphate was well tolerated following the oral administration of a once-daily 200-mg dose for three days. No serious adverse events (AEs) were reported; the most commonly reported AEs were mild bradycardia (n = 2), headache (n = 1), and nausea (n = 1)[1].???????? ?? ?? ? ???
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???????? ?? ??
???( 378)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ZHUHAI HRD PHARMACEUTICAL CO., LTD. | +86-15323984661 |
sales@hrdpharm.com | China | 60 | 58 |
| Protheragen-ING | +86-15618352007 |
info@protheragen-ing.com | United States | 3868 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 |
sales@sdperfect.com | China | 294 | 58 |
| Zibo Wei Bin Import & Export Trade Co. Ltd. | +86-0533-2091136 +86-13355255566 |
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| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 |
sales@sjar-tech.com | China | 538 | 58 |
| Cangzhou Kangrui Pharma Tech Co. Ltd., | +86-18632776803 +86-13833998158 |
cangzhoukangrui@126.com | China | 773 | 58 |
| Moxin Chemicals | +86-17320513646 +86-17320513646 |
anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29640 | 60 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +86-13795318958 |
bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21585 | 55 |
???????? ?? ??:
Torezolid
Tedizolid IMpurity
Tedizolid Impurity 32
Tenofovir Alafenamide
bis(((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl) hydrogen phosphate
(S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Tedizolid Impurity 36
Tamsulosin hydrochloride
Tenofovir disoproxil fumarate
Sitagliptin phosphate monohydrate
Benzyl (4-broMo-3-fluorophenyl)carbaMate
Disodium (1-methyl-4-oxoimidazolidin-2-ylidene)phosphoramidate
TRI-AMMONIUM PHOSPHATE TRIHYDRATE
Pyridoxal phosphate
PIERICIDIN A
2-(1-methyltetrazol-5-yl)pyridine
(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE
CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester