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ETOFIBRATE

ETOFIBRATE ??? ???
?? ??:
31637-97-5
???:
ETOFIBRATE
???(??):
Tricerol;NSC12443;XE-14-543;Lipo-merz;NSC 12443;NSC-12443;ETOFIBRATE;Ethofibrate;ETOFIBRATE USP/EP/BP;Etofibrate, 10 mM in DMSO
CBNumber:
CB7314168
???:
C18H18ClNO5
??? ??:
363.79
MOL ??:
31637-97-5.mol

ETOFIBRATE ??

???
42-44°C
?? ?
486.8±35.0 °C(Predicted)
??
1.2303 (rough estimate)
???
1.6500 (estimate)
?? ??
Sealed in dry,2-8°C
???
?????(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
3.04±0.10(Predicted)
??
???? ?????
???
7.276mg/L(??)
BRN
497931
?? ??
??? ? ???
???(???)
InChI
1S/C18H18ClNO5/c1-18(2,25-15-7-5-14(19)6-8-15)17(22)24-11-10-23-16(21)13-4-3-9-20-12-13/h3-9,12H,10-11H2,1-2H3
InChIKey
XXRVYAFBUDSLJX-UHFFFAOYSA-N
SMILES
O=C(OCCOC(C(C)(C)OC1=CC=C(Cl)C=C1)=O)C2=CC=CN=C2

??

WGK ?? 3
HS ?? 2933.39.4100
???? ??? 11 - Combustible Solids

ETOFIBRATE C??? ??, ??, ??

??

Etofibrate is a combination of niacin and clofibrate that acts as a hypolipidemic agent. In vivo, etofibrate decreases plasma cholesterol and triglyceride concentrations and increases bile cholesterol content in rats. It also decreases thromboxane formation, platelet aggregation, and plasma viscosity and inhibits neointima formation in a carotid artery balloon injury rat model. Formulations containing etofibrate have been used to treat hyperlipidemia.

??? ??

White to Off-White Solid

??

Antilipemic; reducing lipid levels in the blood.

ETOFIBRATE ?? ?? ? ???

???

?? ??


ETOFIBRATE ?? ??

???( 130)?? ??
??? ?? ??? ?? ?? ? ??
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