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(-)-4-????????????

(-)-4-????????????
(-)-4-???????????? ??? ???
?? ??:
62284-79-1
???:
(-)-4-????????????
???(??):
(-)-4-????????????
???:
(-)-4-BROMOTETRAMISOLE OXALATE
???(??):
(-)-p-Bromotetramisole oxalate;(S)-6-(p-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate;R 30402;6-BROMOLEVAMISOLE OXALATE;L-P-BROMOTETRAMISOLE OXALATE;(-)-P-BROMOLEVAMISOLE OXALATE;(-)-4-BROMOTETRAMISOLE OXALATE;Bromotetramisole, L(-) oxalate;(-)-4-BROMOTETRAMISOLE OXALATE;L-(-)-P-BROMOTETRAMISOLE OXALATE
CBNumber:
CB7709111
???:
C13H13BrN2O4S
??? ??:
373.22
MOL ??:
62284-79-1.mol
MSDS ??:
SDS

(-)-4-???????????? ??

???
192 °C (dec.) (lit.)
???
87℃
?? ??
2-8°C
???
???(?? 10mg/ml)
??? ??
??
??
???
?? ??
[α]25/D 104°, c = 0.5 in H2O
BRN
4944883
???
??? ?? ?????? 1? ?? ??????. ??? ??? -20°C?? ?? 3?? ?? ??? ? ????.
InChI
InChI=1/C11H11BrN2S.C2H2O4/c12-9-3-1-8(2-4-9)10-7-14-5-6-15-11(14)13-10;3-1(4)2(5)6/h1-4,10H,5-7H2;(H,3,4)(H,5,6)/t10-;/s3
InChIKey
ZULBIBHDIQCNIS-MEQOOBBNNA-N
SMILES
C(=O)(O)C(=O)O.BrC1C=CC([C@@H]2N=C3SCCN3C2)=CC=1 |&1:11,r|
??
  • ?? ? ?? ??
??? ?? Xn
?? ???? ?? 21/22-36/37/38-20/21/22
????? 24/25-36/37/39-26
WGK ?? 3
F ?????? 10
???? ??? 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Oral
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
NFPA 704
0
2 0

(-)-4-???????????? C??? ??, ??, ??

??

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.

??? ??

white to light yellow crystal powde

Biochem/physiol Actions

(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases.

(-)-4-???????????? ?? ?? ? ???

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(-)-4-???????????? ?? ??

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(-)-4-???????????? ?? ??:

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