BQ-788
BQ-788 ??
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-20°C
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??????: 0.3 mg/mL ? ???
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acetonitrile: 0.3mg/mL DMSO: 1.2mg/mL ethanol: 1.2mg/mL H2O: slightly soluble
InChIKey
IBWYJVKAVOHKHB-IAZAOAQXNA-N
SMILES
C(C1=CN(C(=O)OC)C2=CC=CC=C12)[C@H](C(=O)N[C@@H](C(=O)O)CCCC)NC(=O)[C@H](CC(C)(C)C)NC(N1[C@@H](CCC[C@@H]1C)C)=O.[NaH] |&1:14,18,29,38,42,r|
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WGK ??
3
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11 - Combustible Solids
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Warning
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P- ??
H302
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P264, P270, P301+P312, P330, P501
H315
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?? 2
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P264, P280, P302+P352, P321,P332+P313, P362
H319
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P264, P280, P305+P351+P338,P337+P313P
H335
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?? 3
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P261
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P280
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P301+P312
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P302+P352
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P305+P351+P338
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BQ-788 C??? ??, ??, ??
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BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs), uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs)
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Potent, selective ET B receptor antagonist (IC 50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
Biochem/physiol Actions
Selective ETB endothelin receptor antagonist.
BQ-788 ?? ?? ? ???
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BQ-788 ?? ??
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China 56
Europe 1
Germany 3
India 1
Switzerland 1
United Kingdom 3
United States 16
Global 81