rosoxacin
|
|
rosoxacin ??
- ???
- 290°
- ?? ?
- 500.8±50.0 °C(Predicted)
- ??
- 1.317±0.06 g/cm3(Predicted)
- ?? ??
- Store at -20°C
- ???
- DMF(?? ??)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 6.48±0.41(Predicted)
- ??
- ??? ????? ?????
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ???? ?? | KE-13608 |
|---|
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
| ??·?? ??: |
|
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| ??????: |
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rosoxacin C??? ??, ??, ??
??
Antibacterial.??
ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. An antibacterial drug, active against Neisseria gonorrhoeae, it has be n used for treating urinary tract infections and certain sexually transmitted diseases.Pharmacokinetics
A single oral dose of 300 mg produces a mean peak plasma concentration of 4–5 mg/L at about 2–4 h, with an apparent elimination half-life of about 6 h. Elimination in the urine is partly as the N-oxide metabolite and the glucuronide of this metabolite.Side effects are those common to quinolones, notably gastrointestinal tract and CNS disturbances. About 50% of patients treated with single oral doses of 100–400 mg developed dizziness, drowsiness, altered visual perception and other CNS effects.
It is effective as single-dose treatment of patients with urethral and anorectal gonorrhea, but coexistent C. trachomatis infection is not eliminated from most patients and postgonococcal urethritis develops in up to 30%.
rosoxacin ?? ?? ? ???
???
?? ??
rosoxacin ?? ??
???( 39)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 21193 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32467 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 28675 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 |
market18@leapchem.com | China | 43333 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131956 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 |
marketing@accelachem.com | China | 10975 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 |
ivy@hnhbsj.com | China | 7237 | 62 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12335 | 58 |
| DebyeTec.com Inc. | 18086626237 18086626237 |
2693528373@qq.com | China | 2937 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9804 | 58 |
rosoxacin ?? ??:
4-(4-????)???
2-AMINO-4-METHYLBENZALDEHYDE
3-P-TOLYL-PROPAN-1-OL
1-METHYL-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
3-(4-METHYLPHENYL)PROPIONIC ACID
2-Methyl-3-(4-methylphenyl)prop-1-ene
3-(N-Phenyl-N-methyl)aminoacrolein
3-(4-METHYLPHENYL)PROPIONALDEHYDE
3-DIMETHYLAMINO-2-METHYL-2-PROPENAL
2-Benzylacrylic acid
rosoxacin
4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
4-Phenylpyridine
3-PYRIDIN-4-YLANILINE