6-???-1H-???-3-??
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6-???-1H-???-3-?? ??
- ?? ?
- 408.7±25.0 °C(Predicted)
- ??
- 1.533±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C(protect from light)
- ?? ?? (pKa)
- 13.72±0.40(Predicted)
- ??
- Off-white to pale purple Solid
- InChI
- InChI=1S/C7H6ClN3/c8-4-1-2-5-6(3-4)10-11-7(5)9/h1-3H,(H3,9,10,11)
- InChIKey
- BPTYMRSBTUERSW-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(Cl)=C2)C(N)=N1
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????(GHS): |
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| ??·?? ??: |
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| ??????: |
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6-???-1H-???-3-?? C??? ??, ??, ??
??
Starting from 6-chloro-1H-indazol-3-amine, the EDC/HOAt promoted coupling with the (S)-carboxylic acid derivative furnished (S)-1-(3-Amino-6-chloro-1H-indazol-1-yl)-2-methyl-3-phenoxypro-pan-1-one. This synthesis was performed to explore the structure-activity relationships (SAR) by substituting the indazole scaffold at the 6-position with a chlorine atom, facilitating the identification of novel CFTR potentiators.[1]6-???-1H-???-3-?? ?? ?? ? ???
???
?????
N-??-2-?????
?????, ?????
?? ???
2,4-???? ????
4-Chloro-2-iodoaniline
?????,2-broMo-4-?????-
2-CHLORO-4-HYDRAZINYLBENZONITRILE(WX191485)
2-???-4-??????
2-???-4-????????
4-Chloro-2-fluorobenzonitrile
2,4-Dichlorobenzonitrile
?? ??
6-???-1H-???-3-?? ?? ??
???( 58)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Jinan Honest Pharm Co., Ltd | |
zpy8217@163.com | China | 286 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 52923 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 |
info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 |
sale04@alfachem.cn | China | 9612 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 |
laboratory@coreychem.com | China | 30224 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 |
info@dycnchem.com | China | 52704 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 |
cbc@coresyn.com | China | 9984 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 |
peter68@ptchemgroup.com | China | 35425 | 58 |
6-???-1H-???-3-?? ?? ??:
3-Amino-6-morpholin-4-ylpyridazine
5-CHLORO-1H-INDAZOL-3-YLAMINE
(3-AMINO-5-NITROPHENYL)METHANOL
3-AMINO-4-CYANOPYRIDINE
3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE
3-aMino-5-broMo-4-chloropyridine
3-Amino-6-trifluoromethyl-pyridin-2-ol
3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
3-amino-6-chloropyrazine-2-carboxylic acid
3-AMINO-4-METHOXYPYRIDINE
3-AMINO-3-(4-CYANOPHENYL)PROPANOIC ACID
3-Amino-5-chloropyridin-2-ol HCl
(3-aminopyrazin-2-yl)methanol
3-Amino-3-(4-methoxyphenyl)propionic acid
3-PYRIDINAMINE, 6-(1-METHYLETHYL)-
3-AMINO-5-HYDROXYBENZOIC ACID
2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE
2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE