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2-???????

2-???????
2-??????? ??? ???
?? ??:
142-08-5
???:
2-???????
???(??):
2-????????;2-???????
???:
2-Hydroxypyridine
???(??):
Pyridin-2(1H)-one;2-PYRIDONE;2(1h)-pyridinone;2-Pyridinol;Pyridin-2-one;Pyridinone;α-Pyridone;1h-pyridin-2-one;2-pyridinone;2(1H)-PYRIDONE
CBNumber:
CB8137755
???:
C5H5NO
??? ??:
95.1
MOL ??:
142-08-5.mol
MSDS ??:
SDS

2-??????? ??

???
105-107 °C (lit.)
?? ?
280-281 °C (lit.)
??
1.39
???
1.5939 (estimate)
???
210 °C
?? ??
Sealed in dry,Room Temperature
???
450g/L
?? ?? (pKa)
0.75(at 20℃)
??? ??
??
??
??~??~??, ?? ? ?? ?? ?? ??????.
???
? 450g/L @ 20°C ? ???? ???? ??? ????? ?? ?????.
BRN
105786
InChI
1S/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)
InChIKey
UBQKCCHYAOITMY-UHFFFAOYSA-N
SMILES
Oc1ccccn1
LogP
-0.593 (est)
CAS ??????
142-08-5(CAS DataBase Reference)
NIST
2(1H)-Pyridinone(142-08-5)
EPA
2(1H)-Pyridinone (142-08-5)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi,Xn,T
?? ???? ?? 36/37/38-40-25
????? 26-36-37/39-22-45-36/37/39
????(UN No.) UN2811
WGK ?? 3
RTECS ?? UV1144050
F ?????? 8
TSCA TSCA listed
?? ?? 6.1
???? III
HS ?? 29333990
???? ??? 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
?? LD50 ipr-mus: 410 mg/kg TOXIA6 23,815,85
???? ?? KE-29952
????(GHS): Skull and Crossbones (GHS06)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? P264, P270, P301+P310, P321, P330,P405, P501
??????:
NFPA 704
1
2 0

2-??????? MSDS


2-Hydroxypyridine

2-??????? C??? ??, ??, ??

??? ??

white to light yellow crystal

??

2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis.

??

ChEBI: 2-Hydroxypyridine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. It has a role as a plant metabolite.

?? ??

2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs).

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

Distil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.]

2-??????? ?? ?? ? ???

???

?? ??


2-??????? ?? ??

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2-??????? ?? ??:

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