N-DESMETHYLCLOZAPINE
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N-DESMETHYLCLOZAPINE ??
- ???
- 120-125°C
- ?? ?
- 502.6±60.0 °C(Predicted)
- ??
- 1.38±0.1 g/cm3(Predicted)
- ???
- 9℃
- ?? ??
- Store at RT
- ???
- ?????(?? ???), DMSO, ???(?? ???)
- ??? ??
- ??? ??.
- ?? ?? (pKa)
- 8.49±0.10(Predicted)
- ??
- ?? ????? ?????
- InChI
- 1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
- InChIKey
- JNNOSTQEZICQQP-UHFFFAOYSA-N
- SMILES
- Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
- CAS ??????
- 6104-71-8(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,T,F | ||
|---|---|---|---|
| ?? ???? ?? | 20/22-36/37/38-39/23/24/25-23/24/25-11 | ||
| ????? | 22-36-45-36/37-16-7 | ||
| ????(UN No.) | 3249 | ||
| WGK ?? | 3 | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
N-DESMETHYLCLOZAPINE C??? ??, ??, ??
??? ??
Yellow Crystalline Solid??
N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.??
ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.?? ??
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril and FrazaClo in the US. This Certified Snap-N-Spike Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.???? ??
A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.N-DESMETHYLCLOZAPINE ?? ?? ? ???
???
N-(2-???-4-?????)?????
2-???-5-????????
????
2-[(4-???-2-?????)???]-???
8,11-????-5H-???[b,e][1,4]????
8-???-5,10-????????[b,e][1,4]????-11-?
????
?????
?? ??
N-DESMETHYLCLOZAPINE ?? ??
???( 163)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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| TargetMol Chemicals Inc. | +1-781-999-5354; |
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| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
N-DESMETHYLCLOZAPINE ?? ??:
Prochlorperazine
Agelongine
Anpirtoline hydrochloride
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
Clozapine EP IMpurity D
CLOZAPINE, [N-METHYL-3H]
CLOZAPINE (D4)
GMC 61-39
CLOZAPINE N-OXIDE
N-Desmethyl Clozapine-D8
CLOZAPINE HYDROCHLORIDE
N-DESMETHYLCLOZAPINE
11,11'-(PIPERAZINE-1,4-DIYL)-BIS-8-CHLORO-5H-DIBENZE[B,E][1,4]-DIAZEPINE
Clozapine