S107;CS-2452;S-107,S107;S-107; S 10;S107 free base;S107, 10 mM in DMSO;S 107 hydrochloride;2,3,4,5-Tetrahydro-7-methoxy-4-methyl-;RyR-Calstabin Interaction Stabilizer, S107;7-methoxy-4-methyl-3,5-dihydro-2H-1,4-benzothiazepine
It is a benzothiazepine derivative that binds the RyR1 channel and enhances the binding affinity of Calstabin-1. By preventing the depletion of Calstabin-1 from the RyR1 complex, S 107 slows muscle fatique and reduces muscle damage in exercised mice. In a murine model of Duchenne muscular dystrophy, S 107 reduces biochemical and histological evidence of the muscle damage associated with muscular dystrophy, improves muscle function, and increases exercise performance.
