ChemicalBook >?? ???? >pyrazolo[1,5-a]pyrazine
pyrazolo[1,5-a]pyrazine
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pyrazolo[1,5-a]pyrazine ??
- ??
- 1.29±0.1 g/cm3(Predicted)
- ?? ?? (pKa)
- 0.33±0.30(Predicted)
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pyrazolo[1,5-a]pyrazine C??? ??, ??, ??
Synthesis
A four-step protocol for the synthesis of pyrazolo[1,5-a]pyrazines has been reported by Peter J. Lindsay-Scott and colleagues[1]. Commercially available pyrazoles were alkylated and formylated in a regiocontrolled manner to give pyrazole-5-aldehydes bearing 2,2-dialkoxyethyl substitution on N-1. Efficient conditions for the subsequent deprotection and cyclization of these intermediates allowed access to pyrazolo[1,5-a]pyrazines with multiple substitution patterns.![pyrazolo[1,5-a]pyrazine synthesis](/NewsImg/2025-12-19/6390173872231213755618307.png "pyrazolo[1,5-a]pyrazine synthesis")
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[1] A Flexible Strategy for the Regiocontrolled Synthesis of Pyrazolo[1,5-a]pyrazines. J. Org. Chem. 2017, 82, 20, 11295–11303. DOI: 10.1021/acs.joc.7b02128pyrazolo[1,5-a]pyrazine ?? ?? ? ???
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pyrazolo[1,5-a]pyrazine ?? ??
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pyrazolo[1,5-a]pyrazine ?? ??:
Pyrazolo[1,5-a]pyriMidin-7-ol
Pyrazolo[1,5-a]pyridin-3-amine, hydrochloride (1:1)
pyrazolo[1,5-a]pyrazine-3-carboxylic acid
ETHYL PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLATE
Pyrazolo[1,5-a]pyridine-3-carboxylic acid
7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
Pyrazolo[1,5-a]pyrazin-3-amine
Pyrazolo[1,5-a]pyridine-5-methanol
7-CHLORO-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE
pyrazolo[1,5-a]pyridin-5-ylMethanol
PYRAZOLO[1,5-A]PYRIDIN-3-YLAMINE
Pyrazolo[1,5-a]pyridine, 5-(chloromethyl)-
ethyl pyrazolo[1,5-a]pyrazine-3-carboxylate
PYRAZOLO[1,5-A]PYRIDIN-3-YLAMINE HYDROCHLORIDE