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Pirenzepine

Pirenzepine ??? ???
?? ??:
28797-61-7
???:
Pirenzepine
???(??):
LS-519-C12;pirenzepin;pirenzepine;Gastrozepin;nyl)acetyl)-;Tabe:Ulcuforton;PirenzepineBase;Pirenzepine dihydroc;Pirenzepine USP/EP/BP;Ombitasvir Impurity 2
CBNumber:
CB8694090
???:
C19H21N5O2
??? ??:
351.4
MOL ??:
28797-61-7.mol

Pirenzepine ??

?? ?
541.7±50.0 °C(Predicted)
??
1.271±0.06 g/cm3(Predicted)
?? ??
Store at RT
???
soluble in No data available
?? ?? (pKa)
11.29±0.20(Predicted)
??? ??
solid
??
white
???
water: 100mM
InChI
1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
InChIKey
RMHMFHUVIITRHF-UHFFFAOYSA-N
SMILES
N4(CCN(CC4)C)CC(=O)[n]1c2ncccc2[nH][c](c3c1cccc3)=O

??

WGK ?? WGK 2
???? ??? 11 - Combustible Solids

Pirenzepine C??? ??, ??, ??

??? ??

solid

??

Pirenzepine, is an M1 selective antagonist, that is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm.

???? ??

M 1 muscarinic receptor selective antagonist. Inverse agonist activity reported.

?? ???

This hygroscopic antiulcerative (FWfree-base = 351.41 g/mol; CAS 28797-61- 7) is a gastric acid inhibitor and selective M1 muscarinic receptor antagonist, and the antisecretory properties of pirenzepine on gastric acid and pepsin secretion may be attributed to this antagonistic activity on muscarinic M1 receptors.

Pirenzepine ?? ?? ? ???

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?? ??


Pirenzepine ?? ??

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