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fenspiride

fenspiride ??? ???
?? ??:
5053-06-5
???:
fenspiride
???(??):
DESP;FUBMN24;FUB-MN24;Fenspirid;fenspiride;Fenspiridum;Fenspiride-d5;fenspiride USP/EP/BP;8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one;Pharmaceutical intermediates BKEDBP BKEDBP bkedbp
CBNumber:
CB8875352
???:
C15H20N2O2
??? ??:
260.33
MOL ??:
5053-06-5.mol

fenspiride ??

?? ?
126-127 °C(Press: 2 Torr)
??
1.19±0.1 g/cm3(Predicted)
?? ?? (pKa)
12.44±0.20(Predicted)
??? ??
Solid:particulate/powder
??
White to off-white
LogP
1.798-1.802 at 20℃ and pH6
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): Health Hazard (GHS08)Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H361 ?? ?? ????? ??? ??? ??? ??? ???? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
H412 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 3 P273, P501
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P273 ???? ???? ???.
P281 ???? ?? ???? ?????
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P330 ?? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

fenspiride C??? ??, ??, ??

??

Bronchodilator;anti-adrenergic (β-receptor).

Pharmaceutical Applications

Fenspiride is an antagonist of 5-hydroxytryptamine, whose effect on bronchial smooth muscle expansion is between isoproterenol and theophylline. It also has the effect of unobtrusion-free respiratory tract and air resistance elimination in the lungs. It has the effect of antitussive, antipyretic, analgesic and anti-inflammatory, and the antipyretic and analgesic effect is better than aminopyrine and the anti-inflammatory effect is stronger than bute.

fenspiride ?? ?? ? ???

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?? ??


fenspiride ?? ??

???( 75)?? ??
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fenspiride ?? ??:

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