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Sodium danshensu

Sodium danshensu ??? ???
?? ??:
67920-52-9
???:
Sodium danshensu
???(??):
Salvianic acid A sodium;NSC122009;NCI-C02120;NSC 122009;NSC-122009;dium danshensu;Sodium danshensu;DANSHENSU SODIUM (RG);(±)-DanShenSu sodium sal;Salvia natriuretic peptide
CBNumber:
CB91117913
???:
C9H11NaO5
??? ??:
222.17
MOL ??:
67920-52-9.mol
MSDS ??:
SDS

Sodium danshensu ??

?? ??
Inert atmosphere,2-8°C
???
H2O : 100 mg/mL (454.24 mM; Need ultrasonic)DMSO : 100 mg/mL (454.24 mM; Need ultrasonic)
??? ??
??
??
White-beige
InChI
InChI=1S/C9H10O5.Na.H/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;;/h1-3,8,10-12H,4H2,(H,13,14);;
InChIKey
UPKQTJGQYNOELB-UHFFFAOYSA-N
SMILES
C(C1C=CC(O)=C(O)C=1)C(O)C(=O)O.[NaH]
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 22
????? 24/25
WGK ?? WGK 3
HS ?? 29329990
???? ??? 11 - Combustible Solids
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P330 ?? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

Sodium danshensu C??? ??, ??, ??

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Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities. It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury. Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.

??? ??

White to light brown powder

??

Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.

Sodium danshensu ?? ?? ? ???

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Sodium danshensu ?? ??

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Sodium danshensu ?? ??:

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