ChemicalBook >?? ???? >4-????-4-OL
4-????-4-OL
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4-????-4-OL ??
- ???
- -16°C (estimate)
- ?? ?
- 226.76°C (rough estimate)
- ??
- 0.8565 (estimate)
- ???
- 1.4395 (estimate)
- ?? ?? (pKa)
- 14.36±0.29(Predicted)
- InChI
- InChI=1S/C9H16O/c1-4-6-8-9(3,10)7-5-2/h2,10H,4,6-8H2,1,3H3
- InChIKey
- VWNNGOBVFMFPNE-UHFFFAOYSA-N
- SMILES
- C#CCC(C)(O)CCCC
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4-????-4-OL C??? ??, ??, ??
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4-METHYLOCTIN-4-OL (also known as 4-Methyl-1-octyn-4-ol) serves as a pharmaceutical intermediate in the preparation of Misoprostol. Misoprostol is a synthetic prostaglandin drug used for the prevention and treatment of gastric and duodenal ulcers, induction of labour, and termination of pregnancy.???
Moderately toxic by ingestion. A moderateeye irritant.Synthesis
In a 50 L glass reactor, 2.2 kg (91.6 mol) of metallic magnesium and 20 L of anhydrous tetrahydrofuran were added, and a reaction was initiated by stirring of about 3.21 kg 3-bromopropyne. After the reaction was initiated, the system became black, A mixture of 7.51 kg of 2-hexanone (75 mol), 7.5 kg of 3-bromopropyne (63 mol) and 20 ml of anhydrous tetrahydrofenosine was added dropwise at 25-35 ° C, and the reaction mixture was added dropwise (2-hexanone , Organic phase merger, dry, concentrated crude. The product was purified by distillation under reduced pressure to give 7.5 kg of pure 4-Methyloctin-4-ol with a purity of 97.1% and a yield of 71.4%4-????-4-OL ?? ?? ? ???
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4-????-4-OL ?? ??
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