SAG
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SAG ??
- ?? ?
- 688.6±55.0 °C(Predicted)
- ??
- 1.30±0.1 g/cm3(Predicted)
- ?? ??
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- ???
- DMSO(?? 20mg/ml), DMF(?? 20mg/ml) ?? ???(?? 20mg/ml)? ?????.
- ??? ??
- ????? ??
- ?? ?? (pKa)
- 10+-.0.40(Predicted)
- ??
- ???? ????
- ???
- H2O: 20mg/mL, clear
- ??
- Light Sensitive
- ???
- ???
- InChIKey
- VFSUUTYAEQOIMW-YHBQERECSA-N
- SMILES
- O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????(UN No.) | UN 2811 6.1 / PGIII | ||
|---|---|---|---|
| WGK ?? | WGK 3 | ||
| HS ?? | 2934999090 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 4 |
SAG C??? ??, ??, ??
??? ??
Orange to Red Oil??
Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:- to study its effects on mouse hippocampal cells
- to determine its effects on the mitochondrial network in zebrafish embryo
- to study its effects on murine embryonic fibroblasts
Biochem/physiol Actions
SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.SAG ?? ?? ? ???
???
?? ??
SAG ?? ??
???( 160)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8497 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 |
sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; |
sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 |
market18@leapchem.com | China | 24597 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 9947 | 58 |