??? ?????????
|
|
??? ????????? ??
- ???
- 195-199 °C (dry matter)(lit.)
- ??
- D25 -24 to -26° (c = 5, calculated on anhydrous basis)
- ?? ??
- Store at RT
- ???
- H2O: 50 mg/mL
- ??? ??
- ??
- ??
- ???? ?????
- ???
- H2O: 100mM
- ?? ??
- ??? ? ???
- InChI
- InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3
- InChIKey
- WTGQALLALWYDJH-MLRWSLNSNA-N
- SMILES
- [C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r|
- CAS ??????
- 114-49-8(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22 | ||
| ????? | 36 | ||
| ????(UN No.) | UN 1544 6.1/PG 1 | ||
| WGK ?? | 3 | ||
| RTECS ?? | YM4550000 | ||
| F ?????? | 3-8 | ||
| TSCA | TSCA listed | ||
| HS ?? | 2939800000 | ||
| ???? ??? | 3 - Flammable liquids | ||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
||
| ?? | LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick) |
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Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.??? ??
Off-White Solid??
An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant??
ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.?? ??
Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
??? ?? ??
Sensitive to air, light and moisture. Water soluble.?? ???
Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .????
Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.???? ??
Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.Clinical Use
A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.Purification Methods
The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]??? ????????? ?? ?? ? ???
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???( 481)?? ??
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SCOPOLAMINE N-OXIDE HYDROBROMIDE
Scopolamine Hydrobromide Trihydrate
Scopolamine
Scopolamine butylbromide
(-)-SCOPOLAMINE
HYOSCINE HYDROCHLORIDE
DL-TROPIC ACID
Scopine
DL-(SCOPOLAMINE HYDROBROMIDE)
Cimetropium bromide
DEXTROMETHORPHAN HYDROBROMIDE
HYOSCINE N BUTYL BROMIDE BP
Methscopolamine bromide
SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3)