ChemicalBook >?? ???? >??? ??>??? ??>???? ???>?????

?????

????? ??? ???

?? ??:: 173903-47-4

???:: ?????

???(??):: ?????

???:: TIZOXANIDE

???(??):: 4-ABAH;TIZ;NSC640;NSC 640;NSC-640;TIZOXANIDE;NSC 697856;Tizoxanide, >98%;Desacetyl-nitazoxanide;Nitazoxanide impurity 01

CBNumber:: CB9649941

???:: C10H7N3O4S

??? ??:: 265.25

MOL ??:: 173903-47-4.mol

MSDS ??:: SDS

?? ?? 137

????? ??

???: 279-281°(dec)

??: 1.644±0.06 g/cm3(Predicted)

?? ??: Sealed in dry,Room Temperature

???: DMSO(?? ???), ???(?? ???, ??)

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 6.70±0.50(Predicted)

??: ????? ?? ???

InChI: 1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)

InChIKey: FDTZUTSGGSRHQF-UHFFFAOYSA-N

SMILES: OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1

?? ? ?? ??
?? ? ???? ?? (GHS)

WGK ??	WGK 3
HS ??	2934.10.1000
???? ???	11 - Combustible Solids

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321	(…) ??? ???.
P330	?? ?????.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P362	??? ??? ?? ?? ?? ?????
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
2		0

????? C??? ??, ??, ??

??

Tizoxanide is an active metabolite of the antiparasitic nitazoxanide . Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 μg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC₅₀s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC₅₀s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC₅₀ = 0.15 μM for both).

??? ??

Light Yellow Powder

??

A metabolite of Nitazoxanide; a potent inhibitor of hepatitis B virus and hepatitis C virus.

????? ?? ?? ? ???

???

?? ??

????? ?? ??

???( 137)?? ??

???	??	???	??	?? ?	??
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????? ?? ??:

Nitazoxanide 2-Amino-5-nitrothiazole Nitazoxanide Impurity 2 Thiacloprid Thiamethoxam

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