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Salirasib

Salirasib ??? ???

?? ??:: 162520-00-5

???:: Salirasib

???(??):: FTS;irasib;CS-1744;Salirasib;Unii-mzh0om550m;Salirasib USP/EP/BP;Farnesylthiosalicylate;Salirasib, 10 mM in DMSO;FARNESYLTHIOSALICYLIC ACID;S-Farnesylthiosalicylic acid

CBNumber:: CB9694198

???:: C22H30O2S

??? ??:: 358.54

MOL ??:: 162520-00-5.mol

MSDS ??:: SDS

?? ?? 142

Salirasib ??

???: 64-66°C

?? ?: 486.0±45.0 °C(Predicted)

??: 1.05

?? ??: -20°C

???: DMSO: ???20mg/mL, ??

?? ?? (pKa): 3.50±0.36(Predicted)

??? ??: ??

??: ???? ????

???: ??? ?? ?????? 1? ?? ??????. DMSO ?? ??? ??? -20°C?? ?? 3?? ?? ??? ? ????.

InChI: InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+

InChIKey: WUILNKCFCLNXOK-CFBAGHHKSA-N

SMILES: C(O)(=O)C1=CC=CC=C1SC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C

?? ? ?? ??
?? ? ???? ?? (GHS)

WGK ??	WGK 3
HS ??	2930.90.2900
???? ???	11 - Combustible Solids

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H315	??? ??? ???	????? ?? ?????	?? 2	??		P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??		P264, P280, P305+P351+P338,P337+P313P

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321	(…) ??? ???.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P362	??? ??? ?? ?? ?? ?????

NFPA 704

	0
2		0

Salirasib C??? ??, ??, ??

??

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC₅₀ value of 7.5 μM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-free systems with a K_i value of 2.6 μM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.

??? ??

Pale Yellow Solid

??

Salirasib is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.

Salirasib ?? ?? ? ???

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Salirasib ?? ??

???( 142)?? ??

???	??	???	??	?? ?	??
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5745	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-86-15536356810 +8617392712697	1022@dideu.com	China	28760	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9066	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58

Salirasib ?? ??:

?????? Tyrphostin AG 490 TYRPHOSTIN AG 1296 Imatinib mesylate (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Gefitinib U0126-EtOH SB 202190 ABT 737 Crizotinib Rapamycin Salirasib (E)-3,7-Dimethylocta-2,6-diene-1-thiol (3-METHYL-BUT-2-ENYLSULFANYL)-BENZENE

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