??? ???
|
|
??? ??? ??
- ???
- >300 °C(lit.)
- ?? ??
- 600kg/m3
- ??
- 1.76
- ???
- 173.9 °C
- ?? ??
- Store at +5°C to +30°C.
- ???
- H2O: 100 mg/mL
- ??? ??
- ??
- ?? ?? (pKa)
- 6.40
- ??
- ???
- ??
- ?? ??
- pH ??
- 7.5 - 9 at 29.4 g/l at 25 °C
- ??????(pH)
- 7.0-9.0 (25℃, 50mg/mL in H2O)
- ???? ??
- synthetic
- ???
- 720g/L(25℃)
- ?? ??(λmax)
- λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
- Merck
- 14,8602
- BRN
- 6104939
- ???
- ????. ??, ???, ???? ???? ????.
- ??? ?? ??
- ????
??
???
- InChI
- 1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3
- InChIKey
- NLJMYIDDQXHKNR-UHFFFAOYSA-K
- SMILES
- O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
- LogP
- -1.72
- CAS ??????
- 6132-04-3(CAS DataBase Reference)
- Absorption
- ≤0.015 at 260nm
≤0.015 at 280nm
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 37/38-41-36/37/38 | ||
| ????? | 26-36/37/39-24/25-36 | ||
| WGK ?? | 1 | ||
| RTECS ?? | GE7810000 | ||
| TSCA | Yes | ||
| HS ?? | 2918 15 00 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ?? | LD50 orally in Rabbit: > 8000 mg/kg |
??? ??? C??? ??, ??, ??
??? ??
white powder or colourless crystals??
Trisodium citrate dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent. It used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators.?? ??
Sodium citrate is prepared by adding sodium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is filtered and evaporated to dryness.??
ChEBI: The dihydrate of trisodium citrate.?? ??
Sodium citrate tribasic dihydrate is the tribasic dihydrate sodium salt of citric acid.Pharmaceutical Applications
Sodium citrate, as either the dihydrate or anhydrous material, is widely used in pharmaceutical formulations.It is used in food products, primarily to adjust the pH of solutions. It is also used as a sequestering agent. The anhydrous material is used in effervescent tablet formulations. Sodium citrate is additionally used as a blood anticoagulant either alone or in combination with other citrates such as disodium hydrogen citrate.
Therapeutically, sodium citrate is used to relieve the painful irritation caused by cystitis, and also to treat dehydration and acidosis due to diarrhea.
???? ??
Commonly used laboratory reagentSafety
After ingestion, sodium citrate is absorbed and metabolized to bicarbonate. Although it is generally regarded as a nontoxic and nonirritant excipient, excessive consumption may cause gastrointestinal discomfort or diarrhea. Therapeutically, in adults, up to 15 g daily of sodium citrate dihydrate may be administered orally, in divided doses, as an aqueous solution to relieve the painful irritation caused by cystitis.Citrates and citric acid enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citrate- or citric acid-containing products.
??
Sodium citrate dihydrate is a stable material. Aqueous solutions may be sterilized by autoclaving. On storage, aqueous solutions may cause the separation of small, solid particles from glass containers.The bulk material should be stored in an airtight container in a cool, dry place.
Purification Methods
Crystallise the salt from warm water by cooling to 0o. [Beilstein 3 III 1100, 3 IV 1274.]? ???
Aqueous solutions are slightly alkaline and will react with acidic substances. Alkaloidal salts may be precipitated from their aqueous or hydro-alcohol solutions. Calcium and strontium salts will cause precipitation of the corresponding citrates. Other incompatibilities include bases, reducing agents, and oxidizing agents.Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic products; oral solutions, suspensions, syrups and tablets; nasal, otic, rectal, topical, transdermal, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.??? ??? ?? ?? ? ???
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??? ??? ?? ??:
????(???) ??????? ??? ???, ?? ???? ?? ????, ??? ?????? ??? ???? ??????????????? ???????? ?? ???? ??? ??? ????? ??-??? ????? ??? ?????? ??? ???
Ethyl 4-hydroxybenzoate,sodium salt
Sildenafil citrate
CITRIC ACID TRISODIUM SALT HYDRATE, DNASE, RNASE AND PROTEASE FREE, FOR MOLECULAR BIOLOGY, 99.8%
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, 1,2-dimethyl ester