Altretamine suppliers
Altretamine
- CAS:
- 645-05-6
- MF:
- C9H18N6
- MW:
- 210.28
Suppliers by country/region
Company Type
Properties
- Melting point:
- 171-175 °C (lit.)
- Boiling point:
- 339.81°C (rough estimate)
- Density
- 1.0441 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly, Heated)
- pka
- pKa 10.3 (Uncertain)
- form
- solid
- color
- White to Off-White
- Water Solubility
- Insoluble
- Merck
- 13,318
- InChI
- 1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
- InChIKey
- UUVWYPNAQBNQJQ-UHFFFAOYSA-N
- SMILES
- CN(C)c1nc(nc(n1)N(C)C)N(C)C
- CAS DataBase Reference
- 645-05-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Altretamine(645-05-6)
- EPA Substance Registry System
- Altretamine (645-05-6)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
- target organs
- Respiratory system
- PPE
- dust mask type N95 (US), Eyeshields, Faceshields, Gloves
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- OS1050000
- HS Code
- 2933690000
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
- Hazardous Substances Data
- 645-05-6(Hazardous Substances Data)
- Toxicity
- LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper)
Use
Altretamine is available in 50-mg capsules for oraladministration as a second-line treatment for ovarian cancer.The mechanism of action has not been firmly established, althoughthe spectrum of activity is similar to that for otheralkylating agents; however, cross-resistance is not seen.Cytotoxicity has been correlated with metabolism to give thecarbinolamines, which may form imines capable of crosslinking,or decompose to give formaldehyde, which may reactwith nucleophiles on DNA or proteins. The agent is well absorbedupon oral administration, well distributed, and highly(90%) plasma protein bound. The agent is extensively metabolizedin the liver by CYP to give demethylated metabolites via the previously mentioned carbinolamines. Elimination occursprimarily in the urine as mostly demethylated metaboliteswith a terminal elimination half-life of 4 to 10 hours.Myleosuppression and nausea/vomiting are dose-limitingtoxicities. Other adverse effects include lethargy, agitation,hallucinations, skin rash, and elevations in transaminase levels,flulike symptoms, abdominal cramps, and diarrhea.
151 supplier list of "Altretamine"
- Product Name:Altretamine
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
$8.00
- Product Name: Altretamine
- Products Intro:Purity: 99% | Package: 1KG;8USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:altretamine
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
$30.00-70.00
- Product Name:Altretamine
- Products Intro:Purity: 99.84% | Package: 50mg;30USD|100mg;40USD|200mg;70USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:Altretamine
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:altretamine
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Gamma-butyrolactone
- Product Name:ALTRETAMINE
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
- Product Name:Altretamine
- Products Intro:Purity: > 98 % | CustNote: Please reach out to us for more information about custom solutions.
- Company Type: Reagent
- Country/Region: UNITED STATES
- Product Name:Altretamine
- Products Intro:Purity: 0.95&0.99 | Package: 0.1KG;1KG;1000KG | CustNote: Top Quality
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Triglycol monomethyl ether, CAS 112-35-6,Tetrafluoro-1-propanol, CAS 76-37-9,Aminoacetaldehyde dimethyl acetal, CAS 22483-09-6,Hexachloroethane, CAS 67-72-1,3-Allyloxy-2-Hydroxy-1-Propane,Sodium Salt, CAS 52556-42-0
- Product Name:Altretamine;645-05-6
- Products Intro:Purity: 0.99 | Package: 25KG,200L
- Company Type: Trader
- Country/Region: CHINA