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Properties

Melting point:: 125°C

Boiling point:: 536.21°C (rough estimate)

Density: 1.3268 (rough estimate)

refractive index: 1.6500 (estimate)

storage temp.: 2-8°C

solubility: methanol: 62.5 mg/mL

form: solid

pka: 2.77±0.70(Predicted)

color: white

Merck: 14,6551

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Major Application: pharmaceutical (small molecule)

InChI: InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

InChIKey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N

SMILES: C1(C)NC(C)=C(C(OC(C)C)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OCCOC)=O

CAS DataBase Reference: 66085-59-4(CAS DataBase Reference)

NIST Chemistry Reference: Nimodipine(66085-59-4)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P501

Hazard Codes: Xn

Risk Statements: 20/21/22-48/22

Safety Statements: 36

WGK Germany: 1

RTECS: US7975500

HazardClass: IRRITANT

HS Code: 29333990

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral

Toxicity: LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter)

Use

1.Nimodipine should be used for patients with cerebral edema and intracranial hypertension with caution. Nimodipine metabolites has toxicity. So patients with liver dysfunction should be used with caution. Nimodipine can cause a lowering of blood pressure. For patients with hypertensive subarachnoid hemorrhage or stroke patients, the dosage of antihypertensive drugs should be paid attention to be reduced or temporarily stopped, or the dosage of nimodipine should be reduced. That can produce intestinal pseudo-obstruction, manifested as abdominal distension, decreased bowel sounds. When the above symptoms appears, the dosage should be reduced and observation should be hold. 2.Nimodipine can be secreted by milk. Breast-feeding women should not use. Animal experiments suggest that this product has teratogenicity.