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Properties

Melting point:: 153-156°C

alpha: D20 -42° (c = 0.5 in 95% acetic acid)

storage temp.: Inert atmosphere,Store in freezer, under -20°C

solubility: H₂O: soluble

form: Solid

color: White to Off-White

Sequence: {d-Phe}-Cys-Phe-{d-Trp}-Lys-Thr-{Cys(X)}-{Thr(deoxy)} (disulfide bridge: Cys2-Cys7) (X=N-(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)

Stability:: Hygroscopic

Major Application: pharmaceutical

InChIKey: XQEJFZYLWPSJOV-XJQYZYIXSA-N

SMILES: S1SCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N[C@@H]([C@H](O)C)CO)C(O)C)CCCCN)Cc4c5c([nH]c4)cccc5)Cc3ccccc3)NC(=O)C(N)Cc2ccccc2.OC(=O)C.OC(=O)C

CAS DataBase Reference: 79517-01-4

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319

Precautionary statements: P305+P351+P338

WGK Germany: 3

HS Code: 2937190000

Storage Class: 11 - Combustible Solids

Toxicity: TDLo scu-man: 2587 mg/kg:GIT,LVR LANCAO348,1668,1996

Use

Octreotide is clinically used for the treatment of esophageal varices caused by portal hypertension, acromegaly, gastrointestinal bleeding including cirrhosis, esophageal varices bleeding, peptic ulcer bleeding and stress ulcer bleeding, pancreatic diseases including heavy acute pancreatitis, pancreatic trauma, or pancreatic fistula after surgery, and prevention of complications after pancreas surgery. It is also used for gastrointestinal fistula, digestive endocrine tumors such as vasoactive intestinal peptide tumors, gastrinoma, glucagon tumors, ectopic acth syndrome, carcinoid syndrome, and it is used for acromegaly, exophthalmus hyperthyroidism disease, after the removal of the entire colon appearing persistent and intractable diarrhea, aids-related diarrhea. Intrathecal injection of this product can treat cancer pain.