Topotecan hydrochloride suppliers
Topotecan hydrochloride
- CAS:
- 119413-54-6
- MF:
- C23H24ClN3O5
- MW:
- 457.91
Suppliers by country/region
Company Type
Properties
- Melting point:
- 213-218°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Light yellow to greenish powder.
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- DGHHQBMTXTWTJV-UUTVKYGWNA-N
- SMILES
- C12C=C3N(CC4C=C5C(CN(C)C)=C(O)C=CC5=NC3=4)C(=O)C=1COC(=O)[C@]2(O)CC.Cl |&1:27,r|
- CAS DataBase Reference
- 119413-54-6(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H351-H340-H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38-46
- Safety Statements
- 26-36/37/39-45
- HS Code
- 29420000
Use
Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy. In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The Ⅲ clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome. Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors. Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.
296 supplier list of "Topotecan hydrochloride"
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 99% | Package: 1kg|25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2-Chloromalonaldehyde,(R)-5,7-difluorochroman-4-ol,Cyclobutanecarboxylic acid,(Bromomethyl)cyclobutane,5-Amino-4-imidazolecarboxamide
$2.00
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 99% | Package: 1kg;2USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:Topotecan Hydrochloride
- Products Intro:Purity: 0.98 | Package: 10mg;20mg;50mg;100mg
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Mogroside V,Methysticin,Sarsasapogenin,20(R)-Ginsenoside Rg3,Ginsenoside CK
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 99% HPLC | Package: 1mg;10mg;1kg；10kg；25kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:119413-54-6
- Products Intro:Purity: 0.99 | Package: 5KG;1KG/aluminum foil package; 25kg/drum | CustNote: Paypal,credit card,western union,bank transfer
- Company Type: Trader
- Country/Region: CHINA
- Main Products: hgh191aa,peptides,sarms
- Product Name:topotecan hydrochloride
- Products Intro:Purity: 0.99 | Package: 1kg | CustNote: MG25129
- Company Type: Trader
- Country/Region: CHINA
$30.00-73.00
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 98.71% | Package: 5mg;30USD|10mg;47USD|25mg;73USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 99.9%|Package: 1g
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
- Product Name:Topotecan hydrochloride
- Products Intro:Purity: 98%min | Package: 1g;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Linoleic Acid,Vitamin B12,Riboflavin,β-Nicotinamide Mononucleotide,Amoxicillin trihydrate