1-METHYL-D-TRYPTOPHAN
|
- $29 - $10000
- Product name: 1-METHYL-D-TRYPTOPHAN
- CAS: 110117-83-4
- MF: C12H14N2O2
- MW: 218.25
- EINECS:
- MDL Number:MFCD00274271
- Synonyms:1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;Indoximod (NLG-8189）;NLG-8189;1-Me-D-Trp;D-Trp(Me)-OH
65 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Acrotein
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
Package
- 50mg
- 100mg
- 200mg
- 250mg
- 50
- 500mg
- 1g
- 10mM*1mLinDMSO
- 2000mg
- 5g
- 5000mg
- 10000mg
- 10g
- 25g
- 100G
- 500000mg
- 1000000mg
- Manufactureraablocks
- Product numberAA0032QF
- Product description1-Methyl-D-Tryptophan 97%
- Packaging1g
- Price$65
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0032QF
- Product description1-Methyl-D-Tryptophan 97%
- Packaging5g
- Price$233
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0032QF
- Product description1-Methyl-D-Tryptophan 95%
- Packaging10g
- Price$400
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0032QF
- Product description1-Methyl-D-Tryptophan 95%
- Packaging25g
- Price$800
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0032QF
- Product description1-Methyl-D-Tryptophan ≥95%
- Packaging250mg
- Price$41
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ68901
- Product description1-methyl-D-tryptophan 98%
- Packaging100G
- Price$1470
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ68901
- Product description1-methyl-D-tryptophan 98%
- Packaging100G
- Price$1470
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ68901
- Product description1-methyl-D-tryptophan 98%
- Packaging25G
- Price$490
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ68901
- Product description1-methyl-D-tryptophan 98%
- Packaging25G
- Price$490
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ68901
- Product description1-methyl-D-tryptophan 98%
- Packaging5G
- Price$135
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ68901
- Product description1-methyl-D-tryptophan 98%
- Packaging5G
- Price$135
- Updated2026-05-27
- Buy
- ManufacturerAcrotein
- Product numberNA-2694
- Product description1-Methyl-D-tryptophan 97%
- Packaging5g
- Price$199.5
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberNA-2694
- Product description1-Methyl-D-tryptophan 97%
- Packaging10g
- Price$352.8
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberNA-2694
- Product description1-Methyl-D-tryptophan 97%
- Packaging1g
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerAcrotein
- Product numberNA-2694
- Product description1-Methyl-D-tryptophan 97%
- Packaging1g
- Price$51.1
- Updated2026-05-25
- Buy
- ManufacturerAK Scientific
- Product numberJ52918
- Product description1-Methyl-D-tryptophan 95%
- Packaging10g
- Price$360
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0032QF | 1-Methyl-D-Tryptophan 97% | 1g | $65 | 2026-05-28 | Buy |
| aablocks | AA0032QF | 1-Methyl-D-Tryptophan 97% | 5g | $233 | 2026-05-28 | Buy |
| aablocks | AA0032QF | 1-Methyl-D-Tryptophan 95% | 10g | $400 | 2026-05-28 | Buy |
| aablocks | AA0032QF | 1-Methyl-D-Tryptophan 95% | 25g | $800 | 2026-05-28 | Buy |
| aablocks | AA0032QF | 1-Methyl-D-Tryptophan ≥95% | 250mg | $41 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q68901 | 1-methyl-D-tryptophan 98% | 100G | $1470 | 2026-05-25 | Buy |
| ACHEMBLOCK | Q68901 | 1-methyl-D-tryptophan 98% | 100G | $1470 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q68901 | 1-methyl-D-tryptophan 98% | 25G | $490 | 2026-05-25 | Buy |
| ACHEMBLOCK | Q68901 | 1-methyl-D-tryptophan 98% | 25G | $490 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q68901 | 1-methyl-D-tryptophan 98% | 5G | $135 | 2026-05-25 | Buy |
| ACHEMBLOCK | Q68901 | 1-methyl-D-tryptophan 98% | 5G | $135 | 2026-05-27 | Buy |
| Acrotein | NA-2694 | 1-Methyl-D-tryptophan 97% | 5g | $199.5 | 2026-05-25 | Buy |
| Acrotein | NA-2694 | 1-Methyl-D-tryptophan 97% | 10g | $352.8 | 2026-05-25 | Buy |
| Acrotein | NA-2694 | 1-Methyl-D-tryptophan 97% | 1g | $165 | 2021-12-16 | Buy |
| Acrotein | NA-2694 | 1-Methyl-D-tryptophan 97% | 1g | $51.1 | 2026-05-25 | Buy |
| AK Scientific | J52918 | 1-Methyl-D-tryptophan 95% | 10g | $360 | 2026-06-04 | Buy |
Properties
Melting point :242-245 °C(lit.)
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Major Application :peptide synthesis
InChI :InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N
SMILES :C(O)(=O)[C@@H](CC1C2=C(C=CC=C2)N(C)C=1)N
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Major Application :peptide synthesis
InChI :InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N
SMILES :C(O)(=O)[C@@H](CC1C2=C(C=CC=C2)N(C)C=1)N
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.Related product price
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Fmoc-D-Trp(Boc)-OH
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1-METHYL-D-TRYPTOPHAN
$29-10000 -
5-METHYL-DL-TRYPTOPHAN
$15-79130
