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ChemicalBook >> CAS DataBase List >> N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide price.
  • $8 - $3918.4
  • Product name: N,O-Bis(trimethylsilyl)acetamide
  • CAS: 10416-59-8
  • MF: C8H21NOSi2
  • MW: 203.43
  • EINECS:233-892-7
  • MDL Number:MFCD00008270
  • Synonyms:n-(trimethylsilyl)-acetimidicacitrimethylsilylester ;n-(trimethylsilyl)-ethanimidicacitrimethylsilylester ;Trimethylsilyl N-trimethylsilylacetamidate;NO-Bis (trimethylsilyl) acetamide 90+ % gas chromatography;N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8;Trimethylsilyl (1E)-N-[(E)-trimethylsilyl]ethanimidoate;Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester;Ethanimidicacid,N-(trimethylsilyl)-,trimethylsilylester
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  • aablocks
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  • Manufactureraablocks
  • Product numberAA00396J
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide 98%
  • Packaging5g
  • Price$8
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00396J
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide 98%
  • Packaging10g
  • Price$11
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00396J
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide 98%
  • Packaging25g
  • Price$14
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00396J
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide 95%
  • Packaging100g
  • Price$38
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00396J
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide 98%
  • Packaging250g
  • Price$65
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00396J
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide 98%
  • Packaging500g
  • Price$120
  • Updated2026-05-28
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  • ManufacturerAK Scientific
  • Product numberX7204
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide
  • Packaging100g
  • Price$126
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberORS0004978
  • Product descriptionN,O-BIS(TRIMETHYLSILYL)ACETAMIDE 95.00%
  • Packaging100G
  • Price$2333.1
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberOR5155A
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate 97%
  • Packaging500g
  • Price$96
  • Updated2026-06-04
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  • ManufacturerApolloscientific
  • Product numberOR5155A
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate
  • Packaging500g
  • Price$57
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberOR5155A
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate 97%
  • Packaging100g
  • Price$28
  • Updated2026-06-04
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  • ManufacturerApolloscientific
  • Product numberOR5155A
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate
  • Packaging100g
  • Price$21
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberOR5155A
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate 97%
  • Packaging25g
  • Price$21
  • Updated2026-06-04
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  • ManufacturerArctom
  • Product numberBD-A470462
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate 95%
  • Packaging100g
  • Price$39
  • Updated2026-05-25
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  • ManufacturerArctom
  • Product numberBD-A470462
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate 95%
  • Packaging100g
  • Price$39
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberBD-A470462
  • Product descriptionTrimethylsilyl N-(trimethylsilyl)acetimidate 95%
  • Packaging500g
  • Price$140
  • Updated2026-05-25
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00396J N,O-Bis(trimethylsilyl)acetamide 98% 5g $8 2026-05-28 Buy
aablocks AA00396J N,O-Bis(trimethylsilyl)acetamide 98% 10g $11 2026-05-28 Buy
aablocks AA00396J N,O-Bis(trimethylsilyl)acetamide 98% 25g $14 2026-05-28 Buy
aablocks AA00396J N,O-Bis(trimethylsilyl)acetamide 95% 100g $38 2026-05-28 Buy
aablocks AA00396J N,O-Bis(trimethylsilyl)acetamide 98% 250g $65 2026-05-28 Buy
aablocks AA00396J N,O-Bis(trimethylsilyl)acetamide 98% 500g $120 2026-05-28 Buy
AK Scientific X7204 N,O-Bis(trimethylsilyl)acetamide 100g $126 2021-12-16 Buy
American Custom Chemicals Corporation ORS0004978 N,O-BIS(TRIMETHYLSILYL)ACETAMIDE 95.00% 100G $2333.1 2021-12-16 Buy
Apolloscientific OR5155A Trimethylsilyl N-(trimethylsilyl)acetimidate 97% 500g $96 2026-06-04 Buy
Apolloscientific OR5155A Trimethylsilyl N-(trimethylsilyl)acetimidate 500g $57 2021-12-16 Buy
Apolloscientific OR5155A Trimethylsilyl N-(trimethylsilyl)acetimidate 97% 100g $28 2026-06-04 Buy
Apolloscientific OR5155A Trimethylsilyl N-(trimethylsilyl)acetimidate 100g $21 2021-12-16 Buy
Apolloscientific OR5155A Trimethylsilyl N-(trimethylsilyl)acetimidate 97% 25g $21 2026-06-04 Buy
Arctom BD-A470462 Trimethylsilyl N-(trimethylsilyl)acetimidate 95% 100g $39 2026-05-25 Buy
Arctom BD-A470462 Trimethylsilyl N-(trimethylsilyl)acetimidate 95% 100g $39 2026-05-26 Buy
Arctom BD-A470462 Trimethylsilyl N-(trimethylsilyl)acetimidate 95% 500g $140 2026-05-25 Buy

Properties

Melting point :24 °C
Boiling point :71-73 °C35 mm Hg(lit.)
Density :0.832 g/mL at 20 °C(lit.)
vapor pressure :10 hPa (50 °C)
refractive index :n20/D 1.417(lit.)
Flash point :53 °F
storage temp. :Store below +30°C.
solubility :Miscible with many nonpolar and polar aprotic solvents.
pka :5.82±0.50(Predicted)
form :Crystalline Powder, Crystals and/or Chunks
Specific Gravity :0.832
color :Light yellow or beige to brown
Sensitive :Moisture Sensitive
Hydrolytic Sensitivity :7: reacts slowly with moisture/water
BRN :1306669
InChI :1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+
InChIKey :SIOVKLKJSOKLIF-CMDGGOBGSA-N
SMILES :C\C(O[Si](C)(C)C)=N/[Si](C)(C)C
CAS DataBase Reference :10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference :Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System :Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8)

Safety Information

Symbol(GHS): Flame (GHS02)Corrosion (GHS05)Exclamation Mark (GHS07)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

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