1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE
|
- $32 - $3669
- Product name: 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE
- CAS: 105431-72-9
- MF: C26H21N3O
- MW: 391.46
- EINECS:
- MDL Number:MFCD06245587
- Synonyms:LINOPIRDINE DIHYDROCHLORIDE;1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE;LINOPIRDINE (DUP996);Linopirdine2HCl;DuP 996, 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one;1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one;1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one;linopiridine
51 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 200mg
- 1mlx10mM(inDMSO)
- 50
- 250mg
- 500mg
- 1g
- 5g
- 25g
- 10
- 1mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Packaging2mg
- Price$61
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Packaging5mg
- Price$84
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Packaging10mg
- Price$123
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Packaging25mg
- Price$212
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Packaging50mg
- Price$351
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007EL3
- Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Packaging100mg
- Price$492
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD251411
- Product descriptionLinopirdine 98%
- Packaging100MG
- Price$705
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD251411
- Product descriptionLinopirdine 98%
- Packaging25MG
- Price$285
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5540
- Product descriptionLinopirdine
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5540
- Product descriptionLinopirdine
- Packaging50mg
- Price$547
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003182
- Product descriptionLINOPIRDINE 95.00%
- Packaging50MG
- Price$1068.38
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003182
- Product descriptionLINOPIRDINE 95.00%
- Packaging10MG
- Price$693
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6916
- Product descriptionLinopirdine
- Packaging50mg
- Price$637
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6916
- Product descriptionLinopirdine
- Packaging10mg
- Price$212
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6916
- Product descriptionLinopirdine
- Packaging10mg
- Price$282
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one ≥98% | 1mg | $36 | 2026-05-28 | Buy |
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one | 2mg | $61 | 2026-05-28 | Buy |
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one | 5mg | $84 | 2026-05-28 | Buy |
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one | 10mg | $123 | 2026-05-28 | Buy |
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one | 25mg | $212 | 2026-05-28 | Buy |
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one | 50mg | $351 | 2026-05-28 | Buy |
| aablocks | AA007EL3 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one | 100mg | $492 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD251411 | Linopirdine 98% | 100MG | $705 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD251411 | Linopirdine 98% | 25MG | $285 | 2026-05-27 | Buy |
| AK Scientific | SYN5540 | Linopirdine | 10mg | $160 | 2021-12-16 | Buy |
| AK Scientific | SYN5540 | Linopirdine | 50mg | $547 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003182 | LINOPIRDINE 95.00% | 50MG | $1068.38 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003182 | LINOPIRDINE 95.00% | 10MG | $693 | 2021-12-16 | Buy |
| ApexBio Technology | B6916 | Linopirdine | 50mg | $637 | 2026-05-06 | Buy |
| ApexBio Technology | B6916 | Linopirdine | 10mg | $212 | 2026-05-06 | Buy |
| ApexBio Technology | B6916 | Linopirdine | 10mg | $282 | 2021-12-16 | Buy |
Properties
Melting point :186-186.5 °C
Boiling point :655.9±50.0 °C(Predicted)
Density :1+-.0.06 g/cm3(Predicted)
storage temp. :Desiccate at RT
solubility :DMSO: >10mg/mL
pka :6.01±0.10(Predicted)
form :A crystalline solid
color :white to off-white
Boiling point :655.9±50.0 °C(Predicted)
Density :1+-.0.06 g/cm3(Predicted)
storage temp. :Desiccate at RT
solubility :DMSO: >10mg/mL
pka :6.01±0.10(Predicted)
form :A crystalline solid
color :white to off-white
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 μM in HEK293 cells voltage clamped at -60 mV).Related product price
-
1149-23-1
$4-1545 -
23210-22-2
$17.8-972 -
4-phenethylpyridine
$131-551
Suppliers and manufacturers
Alchem Pharmtech,Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
HANGZHOU LEAP CHEM CO., LTD.
Aladdin Scientific
DAYANG CHEM (HANGZHOU) CO.,LTD
3B Pharmachem (Wuhan) International Co.,Ltd.
VDM Biochemicals
Shanghai Hanhong Scientific Co.,Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
