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ChemicalBook >> CAS DataBase List >> (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone price.
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  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AvaChem
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  • Cayman Chemical
  • ChemScene
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  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
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  • TRC
  • Usbiological
Package
  • 500μg
  • 10mM(in1mLDMSO)
  • 10mM(in 1mL DMSO)
  • 2mg
  • 1
  • 500mg
  • 10mM*1mLinDMSO
  • 1g
  • EvaluationSample
  • 1mg
  • 1unit
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  • 50mg
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  • Manufactureraablocks
  • Product numberAA000Y2K
  • Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99%
  • Packaging5mg
  • Price$130
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y2K
  • Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99%
  • Packaging10mg
  • Price$195
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y2K
  • Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide
  • Packaging50mg
  • Price$686
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y2K
  • Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide
  • Packaging100mg
  • Price$916
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y2K
  • Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide ≥98%
  • Packaging1mg
  • Price$53
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY228574
  • Product descriptionRomidepsin 97.00%
  • Packaging5MG
  • Price$200
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberY228574
  • Product descriptionRomidepsin 97.00%
  • Packaging100MG
  • Price$820
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberY228574
  • Product descriptionRomidepsin 97.00%
  • Packaging25MG
  • Price$315
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberSYN5338
  • Product descriptionRomidepsin
  • Packaging10mg
  • Price$628
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA380298
  • Product descriptionRomidepsin 98+%
  • Packaging10mg
  • Price$942
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA380298
  • Product descriptionRomidepsin 98+%
  • Packaging100mg
  • Price$1416
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA380298
  • Product descriptionRomidepsin 98+%
  • Packaging250mg
  • Price$1416
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA380298
  • Product descriptionRomidepsin 98+%
  • Packaging1mg
  • Price$243
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA380298
  • Product descriptionRomidepsin 98+%
  • Packaging5mg
  • Price$243
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8173
  • Product descriptionRomidepsin(FK228,depsipeptide)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8173
  • Product descriptionRomidepsin (FK228, depsipeptide)
  • PackagingEvaluationSample
  • Price$30
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000Y2K Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99% 5mg $130 2026-05-25 Buy
aablocks AA000Y2K Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99% 10mg $195 2026-05-25 Buy
aablocks AA000Y2K Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 50mg $686 2026-05-25 Buy
aablocks AA000Y2K Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 100mg $916 2026-05-25 Buy
aablocks AA000Y2K Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide ≥98% 1mg $53 2026-05-25 Buy
ACHEMBLOCK Y228574 Romidepsin 97.00% 5MG $200 2026-05-27 Buy
ACHEMBLOCK Y228574 Romidepsin 97.00% 100MG $820 2026-05-27 Buy
ACHEMBLOCK Y228574 Romidepsin 97.00% 25MG $315 2026-05-27 Buy
AK Scientific SYN5338 Romidepsin 10mg $628 2021-12-16 Buy
Ambeed A380298 Romidepsin 98+% 10mg $942 2021-12-16 Buy
Ambeed A380298 Romidepsin 98+% 100mg $1416 2021-12-16 Buy
Ambeed A380298 Romidepsin 98+% 250mg $1416 2021-12-16 Buy
Ambeed A380298 Romidepsin 98+% 1mg $243 2021-12-16 Buy
Ambeed A380298 Romidepsin 98+% 5mg $243 2021-12-16 Buy
ApexBio Technology A8173 Romidepsin(FK228,depsipeptide) 1unit $28 2021-12-16 Buy
ApexBio Technology A8173 Romidepsin (FK228, depsipeptide) EvaluationSample $30 2026-05-06 Buy

Properties

Melting point :219-224°C
Boiling point :942.8±65.0 °C(Predicted)
Density :1.174
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
form :powder
pka :11.33±0.60(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :OHRURASPPZQGQM-RGTIDSFYNA-N
SMILES :[C@@]12([H])NC(=O)[C@@]([H])(C(C)C)NC(=O)C[C@@]([H])(C=CCCSSC1)OC(=O)[C@H](C(C)C)NC(=O)/C(=C/C)/NC2=O |c:16,&1:0,5,14,26,r|

Safety Information

Symbol(GHS): Health Hazard (GHS08)Environment (GHS09)Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P363 Wash contaminated clothing before reuse.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent inhibition of HDACs 1, 2, 3, and 8 (IC50s = 53, 39, 53, and 26 nM, respectively), with less potency against HDACs 4, 6, 7, and 9 (IC50s = 470, 330, 3,200, and 12,000 nM, respectively). Through its effects on HDACs, romidepsin has anti-cancer activities, particularly against certain T cell lymphomas.

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