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ChemicalBook >> CAS DataBase List >> 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one price.
  • $36 - $3772
  • Product name: 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one
  • CAS: 1286739-19-2
  • MF: C29H28ClN7OS
  • MW: 558.1
  • EINECS:-0
  • MDL Number:MFCD25976723
  • Synonyms:6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one;Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-;6-(2-chloro-4-(thiazol-5-yl)phenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one;FRAX597, >=98%;6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one USP/EP/BP;6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one;FRAX 597;FRAX-597;FRAX597
61 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Synthonix
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • 2.5mg
  • 10mM(in1mLDMSO)
  • 500mg
  • 50
  • 10
  • 1g
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 250mg
  • 2mg
  • 50mg
  • 100MG
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA000Y78
  • Product descriptionFRAX597 98+%
  • Packaging1mg
  • Price$36
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y78
  • Product descriptionFRAX597 ≥98%(HPLC)
  • Packaging5mg
  • Price$48
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y78
  • Product descriptionFRAX597 ≥98%(HPLC)
  • Packaging10mg
  • Price$86
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y78
  • Product descriptionFRAX597 98+%
  • Packaging25mg
  • Price$164
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000Y78
  • Product descriptionFRAX597 98+%
  • Packaging50mg
  • Price$261
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT94893
  • Product descriptionFRAX597 98%
  • Packaging25MG
  • Price$155
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT94893
  • Product descriptionFRAX597 98%
  • Packaging100MG
  • Price$405
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2182DU
  • Product descriptionCID70934541
  • Packaging5mg
  • Price$282
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2182DU
  • Product descriptionCID70934541
  • Packaging1mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging25mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging2mg
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging50mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging250mg
  • Price$645
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA123005
  • Product descriptionFRAX597 98+%
  • Packaging100mg
  • Price$323
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000Y78 FRAX597 98+% 1mg $36 2026-05-25 Buy
aablocks AA000Y78 FRAX597 ≥98%(HPLC) 5mg $48 2026-05-25 Buy
aablocks AA000Y78 FRAX597 ≥98%(HPLC) 10mg $86 2026-05-25 Buy
aablocks AA000Y78 FRAX597 98+% 25mg $164 2026-05-25 Buy
aablocks AA000Y78 FRAX597 98+% 50mg $261 2026-05-25 Buy
ACHEMBLOCK T94893 FRAX597 98% 25MG $155 2026-05-27 Buy
ACHEMBLOCK T94893 FRAX597 98% 100MG $405 2026-05-27 Buy
AK Scientific 2182DU CID70934541 5mg $282 2021-12-16 Buy
AK Scientific 2182DU CID70934541 1mg $140 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 25mg $140 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 10mg $108 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 5mg $72 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 2mg $37 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 50mg $182 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 250mg $645 2021-12-16 Buy
Ambeed A123005 FRAX597 98+% 100mg $323 2021-12-16 Buy

Properties

Melting point :>220°C (dec.)
storage temp. :Refrigerator
solubility :DMSO (Slightly)
form :Solid
color :Yellow
InChIKey :DHUJCQOUWQMVCG-UHFFFAOYSA-N

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

p21-activated kinases (Paks) are serine/threonine protein kinases involved in cellular signaling pathways. PAK1 is an effector of Rho GTPase. PAKs are oncogenic kinases, which have been implicated as potential therapeutic targets. FRAX 597 is a PAK1 inhibitor that can reduce pancreatic cancer growth when used with Gemcitabine (G305000), an antineoplastic agent.

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