10-Propargyl-10-deazaaminopterin
|
- $44 - $4741
- Product name: 10-Propargyl-10-deazaaminopterin
- CAS: 146464-95-1
- MF: C23H23N7O5
- MW: 477.47
- EINECS:
- MDL Number:MFCD00920897
- Synonyms:N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid;10-Propargyl-10-deazaaminopterin;L-Glutamic acid, N-(4-(1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-;Unii-A8Q8I19Q20;FOLOTYN PRALATREXATE;N-(4-{1-[(2,4-diaMinopteridin-6-yl)Methyl]but-3-yn-1-yl}benzoyl)-L-glutaMic acid;N-[4-[1-[(2,4-DiaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]benzoyl]-L-glutaMic Acid;(2S)-2-(4-(1-(2,4-diaMinopteridin-6-yl)pent-4-yn-2-yl)benzaMido)pentanedioic acid
87 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 50.00g
- 100.00g
- 200mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(1mLinDMSO)
- 10mM(in 1mL DMSO)
- 250.00g
- 5 mg
- 25 mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 2mg
- 5mg
- 10mg
- 10mM(in1mLDMSO)
- 25MG
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98
- Packaging10mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98%
- Packaging50mg
- Price$106
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98%
- Packaging100mg
- Price$170
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98%
- Packaging250mg
- Price$273
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98
- Packaging5mg
- Price$75
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98
- Packaging2mg
- Price$56
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98
- Packaging1mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001DZQ
- Product descriptionN-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98%
- Packaging1g
- Price$1007
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging1G
- Price$1050
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging5MG
- Price$45
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging5MG
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging100MG
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging100MG
- Price$280
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging25MG
- Price$100
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging25MG
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005288
- Product descriptionPRALATREXATE 95.00%
- Packaging10MG
- Price$2000
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98 | 10mg | $99 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98% | 50mg | $106 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98% | 100mg | $170 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98% | 250mg | $273 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98 | 5mg | $75 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98 | 2mg | $56 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98 | 1mg | $44 | 2026-05-28 | Buy |
| aablocks | AA001DZQ | N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid 98% | 1g | $1007 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 1G | $1050 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 5MG | $45 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 5MG | $45 | 2021-12-16 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 100MG | $395 | 2021-12-16 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 100MG | $280 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 25MG | $100 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 25MG | $145 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005288 | PRALATREXATE 95.00% | 10MG | $2000 | 2021-12-16 | Buy |
Properties
Melting point :215 °C(dec.)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
Water Solubility :Insoluble in water
solubility :≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka :3.53±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
InChIKey :OGSBUKJUDHAQEA-WMCAAGNKSA-N
SMILES :C(O)(=O)[C@H](CCC(O)=O)NC(=O)C1=CC=C(C(CC2C=NC3C(N=2)=C(N)N=C(N)N=3)CC#C)C=C1
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
Water Solubility :Insoluble in water
solubility :≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka :3.53±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
InChIKey :OGSBUKJUDHAQEA-WMCAAGNKSA-N
SMILES :C(O)(=O)[C@H](CCC(O)=O)NC(=O)C1=CC=C(C(CC2C=NC3C(N=2)=C(N)N=C(N)N=3)CC#C)C=C1
Safety Information
| Symbol(GHS): |
 
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
Pralatrexate, an injectable DHFR inhibitor, was launched for the treatment of patients with relapsed or refractory PTCL. PTCL is an aggressive form of non-Hodgkin’s lymphoma (NHL) characterized by the proliferation of abnormal T-lymphocytes that circulate in the peripheral bloodstream. The inhibition of the folate enzymes DHFR and thymidylate synthase is a well-validated method of cancer treatment. In vitro, pralatrexate is slightly less potent than MTX in inhibiting DHFR derived from murine leukemia L1210 cells (Ki = 18.2 pM vs. 5.75 pM) and human leukemia CCRF-CEM cells (Ki = 13.4 pM vs. 5.4 pM). However, it is transported into both types of cells with 10-fold higher efficiency than MTX, thereby providing a more potent inhibition of cell growth as compared with MTX. In vivo, intraperitonally administered pralatrexate at 60 mg/ kg twice weekly for three or four doses caused complete lymphoma regressions in 89, 56, and 30% of HT, RL, and SKI-DLBCL-1 xenografted mice, respectively, whereas a similar dosing of MTX at 40 mg/kg twice weekly did not produce complete regression. The posttreatment tumor diameter was also smaller in pralatrexate-treated animals.Related product price
-
L-Glutamic acid
$5-6413.62 -
Aminopterin
$32-3020 -
Lithium diisopropylamide
$60-7033.95
Suppliers and manufacturers
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Henan Tianfu Chemical Co.,Ltd.
Lianyungang happen teng technology co., LTD
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Shanxi Xuanran Import and Export Trade Co., Ltd.
Dideu Industries Group Limited
AFINE CHEMICALS LIMITED
Pralatrexate
CAS:146464-95-1
