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ChemicalBook >> CAS DataBase List >> TETRAETHYL METHYLENEDIPHOSPHONATE

TETRAETHYL METHYLENEDIPHOSPHONATE

TETRAETHYL METHYLENEDIPHOSPHONATE price.
  • $5 - $2868.83
  • Product name: TETRAETHYL METHYLENEDIPHOSPHONATE
  • CAS: 1660-94-2
  • MF: C9H22O6P2
  • MW: 288.21
  • EINECS:216-764-5
  • MDL Number:MFCD00039887
  • Synonyms:methylenedi-phosphonicacitetraethylester ;METHYLENEDIPHOSPHONIC ACID TETRAETHYL ESTER;AURORA KA-1506;BIS(DIETHOXYPHOSPHINYL)METHANE;TETRAETHYL(METHYLENE)BISPHOSPHONATE;TETRAETHYL METHYLENEDIPHOSPHONATE;Tetraethyl methylenediphosphonate, 98+%;methanediyl-bis-phosphonic acid tetraethyl ester
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  • aablocks
  • AHH
  • AK Scientific
  • American Custom Chemicals Corporation
  • Apolloscientific
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Oakwood
  • Sigma-Aldrich
  • SynQuest Laboratories
  • Synthonix
  • TCI Chemical
  • Thermo Scientific Chemicals
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Package
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  • Manufactureraablocks
  • Product numberAA003UL1
  • Product descriptionTetraethyl methylenebis(phosphonate) 98%
  • Packaging1g
  • Price$5
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003UL1
  • Product descriptionTetraethyl methylenebis(phosphonate) 98%
  • Packaging5g
  • Price$8
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003UL1
  • Product descriptionTetraethyl methylenebis(phosphonate) 98%
  • Packaging10g
  • Price$11
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003UL1
  • Product descriptionTetraethyl methylenebis(phosphonate) 98%
  • Packaging25g
  • Price$18
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003UL1
  • Product descriptionTetraethyl methylenebis(phosphonate) 98%
  • Packaging50g
  • Price$32
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003UL1
  • Product descriptionTetraethyl methylenebis(phosphonate) 98%
  • Packaging100g
  • Price$56
  • Updated2026-05-28
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  • ManufacturerAHH
  • Product numberMT-17861
  • Product descriptionMethylenediphosphonicacidtetraethylester 98%
  • Packaging100g
  • Price$625
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-17861
  • Product descriptionMethylenediphosphonic acid tetraethyl ester 97%
  • Packaging100g
  • Price$625
  • Updated2026-05-25
  • Buy
  • ManufacturerAHH
  • Product numberMT-17861
  • Product descriptionMethylenediphosphonic acid tetraethyl ester 97%
  • Packaging100g
  • Price$625
  • Updated2026-05-26
  • Buy
  • ManufacturerAK Scientific
  • Product numberX4451
  • Product descriptionTetraethyl methylenediphosphonate
  • Packaging25g
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX4451
  • Product descriptionTetraethyl methylenediphosphonate
  • Packaging100g
  • Price$527
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ91196
  • Product descriptionTetraethyl methylenediphosphonate
  • Packaging5g
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ91196
  • Product descriptionTetraethyl methylenediphosphonate
  • Packaging1g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0092278
  • Product descriptionTETRAETHYL(METHYLENE)BISPHOSPHONATE 95.00%
  • Packaging25G
  • Price$1193.77
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0092278
  • Product descriptionTETRAETHYL(METHYLENE)BISPHOSPHONATE 95.00%
  • Packaging100G
  • Price$2868.83
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR10799
  • Product descriptionTetraethyl (methylene)bisphosphonate 97%
  • Packaging25g
  • Price$90
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003UL1 Tetraethyl methylenebis(phosphonate) 98% 1g $5 2026-05-28 Buy
aablocks AA003UL1 Tetraethyl methylenebis(phosphonate) 98% 5g $8 2026-05-28 Buy
aablocks AA003UL1 Tetraethyl methylenebis(phosphonate) 98% 10g $11 2026-05-28 Buy
aablocks AA003UL1 Tetraethyl methylenebis(phosphonate) 98% 25g $18 2026-05-28 Buy
aablocks AA003UL1 Tetraethyl methylenebis(phosphonate) 98% 50g $32 2026-05-28 Buy
aablocks AA003UL1 Tetraethyl methylenebis(phosphonate) 98% 100g $56 2026-05-28 Buy
AHH MT-17861 Methylenediphosphonicacidtetraethylester 98% 100g $625 2021-12-16 Buy
AHH MT-17861 Methylenediphosphonic acid tetraethyl ester 97% 100g $625 2026-05-25 Buy
AHH MT-17861 Methylenediphosphonic acid tetraethyl ester 97% 100g $625 2026-05-26 Buy
AK Scientific X4451 Tetraethyl methylenediphosphonate 25g $190 2021-12-16 Buy
AK Scientific X4451 Tetraethyl methylenediphosphonate 100g $527 2021-12-16 Buy
AK Scientific J91196 Tetraethyl methylenediphosphonate 5g $46 2021-12-16 Buy
AK Scientific J91196 Tetraethyl methylenediphosphonate 1g $10 2021-12-16 Buy
American Custom Chemicals Corporation CHM0092278 TETRAETHYL(METHYLENE)BISPHOSPHONATE 95.00% 25G $1193.77 2021-12-16 Buy
American Custom Chemicals Corporation CHM0092278 TETRAETHYL(METHYLENE)BISPHOSPHONATE 95.00% 100G $2868.83 2021-12-16 Buy
Apolloscientific OR10799 Tetraethyl (methylene)bisphosphonate 97% 25g $90 2026-06-04 Buy

Properties

Boiling point :171-174 °C11 mm Hg(lit.)
Density :1.16 g/mL at 25 °C(lit.)
refractive index :n20/D 1.442(lit.)
Flash point :>230 °F
storage temp. :Inert atmosphere,Room Temperature
solubility :Chloroform (Sparingly), Methanol (Slightly)
form :Liquid
Specific Gravity :1.160
color :Clear yellow to yellow-brown
Water Solubility :Slightly miscible with water.
BRN :1813241
InChI :InChI=1S/C9H22O6P2/c1-5-12-16(10,13-6-2)9-17(11,14-7-3)15-8-4/h5-9H2,1-4H3
InChIKey :STJWVOQLJPNAQL-UHFFFAOYSA-N
SMILES :C(P(=O)(OCC)OCC)P(=O)(OCC)OCC
CAS DataBase Reference :1660-94-2(CAS DataBase Reference)
EPA Substance Registry System :Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.

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