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ChemicalBook >> CAS DataBase List >> N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide price.
  • $186 - $2400
  • Product name: N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide
  • CAS: 184036-34-8
  • MF: C18H15ClN2O6S2
  • MW: 454.9
  • EINECS:
  • MDL Number:MFCD00945687
  • Synonyms:N-(4-chloro-3-methyl-2,3-dihydrooxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide;N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide;N-(4-Chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfo;N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3;N-(4-chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfonamide;D07171;Sitax;N- (4- chloro- 3- Methyl- oxazol- 5- yl)- 2- [2- (6- Methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophen
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  • aablocks
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging1mg
  • Price$186
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging5mg
  • Price$193
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging10mg
  • Price$215
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging20mg
  • Price$279
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging50mg
  • Price$350
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging100mg
  • Price$436
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging500mg
  • Price$708
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0039SD
  • Product descriptionN-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90%
  • Packaging1g
  • Price$1043
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging25MG
  • Price$1560
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging25MG
  • Price$1560
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging5MG
  • Price$940
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging5MG
  • Price$940
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging100MG
  • Price$2400
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging100MG
  • Price$2400
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging1MG
  • Price$360
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberS78000
  • Product descriptionSitaxentan 97%
  • Packaging1MG
  • Price$360
  • Updated2026-05-27
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 1mg $186 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 5mg $193 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 10mg $215 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 20mg $279 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 50mg $350 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 100mg $436 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 500mg $708 2026-05-28 Buy
aablocks AA0039SD N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 90% 1g $1043 2026-05-28 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 25MG $1560 2026-05-25 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 25MG $1560 2026-05-27 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 5MG $940 2026-05-25 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 5MG $940 2026-05-27 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 100MG $2400 2026-05-25 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 100MG $2400 2026-05-27 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 1MG $360 2026-05-25 Buy
ACHEMBLOCK S78000 Sitaxentan 97% 1MG $360 2026-05-27 Buy

Properties

Melting point :42-45°
Boiling point :663.9±65.0 °C(Predicted)
Density :1.558
storage temp. :2-8°C
solubility :DMSO
form :Powder
pka :4.96±0.10(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Sitaxsentan is a selective endothelin-A (ETA) receptor antagonist launched for the treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity. It is the second ET receptor antagonist to be marketed for this indication behind bosentan. PAH encompasses a heterogeneous group of disorders characterized by inappropriate overactivation of the endothelin system and is characterized by a progressive increase in pulmonary vascular resistance resulting from vascular remodeling, vasoconstriction, and cellular proliferation. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation of ETA and ETB receptors. ETA receptors are found primarily on smooth muscle cells and, when activated, induce vasoconstriction and cellular proliferation. ETB receptors are expressed in both pulmonary vascular endothelial cells and smooth muscle cells, and their activation is associated with the renal and pulmonary clearance of ET.

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