2-Acetylphenothiazine
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- $8 - $2632.89
- Product name: 2-Acetylphenothiazine
- CAS: 6631-94-3
- MF: C14H11NOS
- MW: 241.31
- EINECS:229-626-4
- MDL Number:MFCD00005017
- Synonyms:2-ACETYLPHENOTHIAZINE;methyl phenothiazin-2-yl ketone;2-Acetyl-10H-phenothiazine;2-Acetylphenothiazin;1-(10H-Phenothiazin-2-yl)ethan-1- one, 2-Ethanoyl-10H-phenothiazine;ML 171;LABOTEST-BB LT00012652;NOX1 Inhibitor, ML171
82 prices
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Brand
- A2B
- aablocks
- AHH
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Biosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- Medical Isotopes, Inc.
- Sigma-Aldrich
- SynQuest Laboratories
- TCI Chemical
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1mg
- 10mg
- 25mg
- 10mM(in1mLDMSO)
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 5g
- 10g
- 25g
- 50g
- 100g
- 500g
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging25mg
- Price$9
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging1g
- Price$10
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging1mg
- Price$8
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging5g
- Price$28
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging10g
- Price$33
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging25g
- Price$70
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging50g
- Price$131
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAD10151
- Product description1-(10H-phenothiazin-2-yl)ethanone 97%
- Packaging100g
- Price$213
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone ≥98%
- Packaging50g
- Price$145
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone ≥98%
- Packaging25g
- Price$77
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone ≥98%
- Packaging10g
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone 98%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone 98%
- Packaging25mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone 98%
- Packaging100mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone 98%
- Packaging1g
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006NE3
- Product description1-(10H-Phenothiazin-2-Yl)Ethanone ≥98%
- Packaging100g
- Price$236
- Updated2026-05-28
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 25mg | $9 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 1g | $10 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 1mg | $8 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 5g | $28 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 10g | $33 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 25g | $70 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 50g | $131 | 2026-05-25 | Buy |
| A2B | AD10151 | 1-(10H-phenothiazin-2-yl)ethanone 97% | 100g | $213 | 2026-05-25 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone ≥98% | 50g | $145 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone ≥98% | 25g | $77 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone ≥98% | 10g | $36 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone 98% | 1mg | $8 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone 98% | 25mg | $10 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone 98% | 100mg | $12 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone 98% | 1g | $15 | 2026-05-28 | Buy |
| aablocks | AA006NE3 | 1-(10H-Phenothiazin-2-Yl)Ethanone ≥98% | 100g | $236 | 2026-05-28 | Buy |
Properties
Melting point :180-185 °C (lit.)
Boiling point :455.7±34.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :-2.45±0.20(Predicted)
form :Dark yellow-orange powder
color :Yellow to Dark Orange
λmax :244nm(MeOH)(lit.)
InChI :InChI=1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3
InChIKey :JWGBOHJGWOPYCL-UHFFFAOYSA-N
SMILES :C(=O)(C1=CC=C2C(=C1)NC1=C(C=CC=C1)S2)C
CAS DataBase Reference :6631-94-3(CAS DataBase Reference)
Boiling point :455.7±34.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :-2.45±0.20(Predicted)
form :Dark yellow-orange powder
color :Yellow to Dark Orange
λmax :244nm(MeOH)(lit.)
InChI :InChI=1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3
InChIKey :JWGBOHJGWOPYCL-UHFFFAOYSA-N
SMILES :C(=O)(C1=CC=C2C(=C1)NC1=C(C=CC=C1)S2)C
CAS DataBase Reference :6631-94-3(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.Related product price
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